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Ugeskrift For Laeger Dec 2020Occupational hand eczema (HE) has continuously been the most frequently recognised occupational disease, comprising > 95% of all recognised occupational skin diseases.... (Review)
Review
Occupational hand eczema (HE) has continuously been the most frequently recognised occupational disease, comprising > 95% of all recognised occupational skin diseases. Irritant contact dermatitis constitutes > 70%, where wet work is the main eliciting factor. Knowledge on the dose-response relationship between wet work and HE is pivotal concerning preventive interventions, job counselling and medico-legal regulations, which is summarised in this review. New findings indicate a significant risk of having HE at an exposure level of no more than 30 minutes of wet work per day.
Topics: Dermatitis, Irritant; Dermatitis, Occupational; Eczema; Hand; Hand Dermatoses; Humans; Occupational Exposure
PubMed: 33463511
DOI: No ID Found -
Journal of the American Veterinary... Dec 2019
Topics: Alligators and Crocodiles; Animals; Citrobacter; Dermatitis; Male; Mycobacterium avium
PubMed: 31793839
DOI: 10.2460/javma.255.12.1349 -
Acta Dermatovenerologica Alpina,... Jun 2006Atopic dermatitis has a significant impact on both the pediatric and adult population worldwide, which has triggered extensive research on the topic. However, various... (Review)
Review
Atopic dermatitis has a significant impact on both the pediatric and adult population worldwide, which has triggered extensive research on the topic. However, various limitations have created difficulties both in making accurate diagnoses and effectively managing atopic dermatitis patients. This review summarizes the current knowledge in the field, providing an overview of the pathophysiology, disease progression, clinical presentation, and diagnosis and treatment of atopic dermatitis.
Topics: Dermatitis, Atopic; Diagnosis, Differential; Environmental Exposure; Humans
PubMed: 16998605
DOI: No ID Found -
Oncology (Williston Park, N.Y.) Dec 2017Radiation therapy (RT) is a frequently used modality for cancer treatment. Acute and/or chronic skin changes may occur and carry risk of influencing quality of life...
Radiation therapy (RT) is a frequently used modality for cancer treatment. Acute and/or chronic skin changes may occur and carry risk of influencing quality of life during and after completion of RT. Radiation reactions may lead to delays in treatment, diminished cosmesis, and functional deficits. Lifestyle factors, treatment modalities, topical agents, and, in some cases, wound dressings may be utilized to help prevent or ameliorate radiation-induced skin reactions. While rigorous evidence supporting specific interventions may be lacking or contradictory, this article summarizes the current knowledge of the etiology, manifestations, and interventions available for prevention and management of radiation dermatitis. Further well-designed studies are needed to confirm the efficacy of current recommendations and facilitate development of novel strategies for optimal care of patients with radiation dermatitis.
Topics: Humans; Radiodermatitis
PubMed: 29297172
DOI: No ID Found -
The British Journal of Dermatology Dec 2022A high prevalence of skin sensitization and dermatitis has been reported among workers exposed to epoxy components.
BACKGROUND
A high prevalence of skin sensitization and dermatitis has been reported among workers exposed to epoxy components.
OBJECTIVES
To estimate the risk of skin sensitization and dermatitis among workers exposed to epoxy components during production of wind turbine blades while using comprehensive safety measures.
METHODS
A cross-sectional study of 180 highly epoxy-exposed production workers and 41 nonexposed office workers was conducted at two wind turbine blade factories in Denmark. Participants underwent a skin examination, were tested with a tailored patch test panel including epoxy-containing products used at the factories, and answered a questionnaire.
RESULTS
Sixteen production workers (8·9%) were sensitized to an epoxy component compared with none of the office workers. Skin sensitization was more frequent within the first year of exposed employment. Strong selection bias by atopic status was indicated. Among nonatopic workers, the prevalence of dermatitis was higher among production workers (16·4%) than among office workers [6·5%, odds ratio (OR) 2·3, 95% confidence interval (CI) 0·6-9·1] and higher among the sensitized workers (43·8%) than the nonsensitized workers (14·6%, OR 4·5, 95% CI 1·6-12·7). Resins based on diglycidyl ether of bisphenol A and F were the most frequent sensitizers. One of the four workers sensitized to epoxy components used at the factories did not react to the epoxy resin of the TRUE test panel.
CONCLUSIONS
Despite comprehensive skin protection, sensitization and dermatitis are prevalent among highly epoxy-exposed workers in the wind turbine industry in Denmark. Our findings document the need for intensified preventive efforts and emphasize the importance of tailored patch testing. What is already known about this topic? Epoxy components are well-known sensitizers of the skin. A high prevalence of skin sensitization and dermatitis has been reported among workers exposed to epoxy components. Comprehensive protective equipment is recommended when working with epoxy components. What does this study add? Despite comprehensive skin protection, skin sensitization and dermatitis are prevalent among epoxy-exposed workers. We found that 40% of workers sensitized to epoxy products had dermatitis. Only 75% of the sensitized workers were detected by the epoxy resin of the TRUE test , which emphasizes the importance of tailored testing.
Topics: Humans; Epoxy Resins; Dermatitis, Occupational; Dermatitis, Allergic Contact; Prevalence; Cross-Sectional Studies; Patch Tests
PubMed: 35972390
DOI: 10.1111/bjd.21830 -
Indian Journal of Dermatology,... 2011Lichenoid tissue reaction or interface dermatitis embrace several clinical conditions, the prototype of which is lichen planus and its variants, drug induced lichenoid... (Review)
Review
Lichenoid tissue reaction or interface dermatitis embrace several clinical conditions, the prototype of which is lichen planus and its variants, drug induced lichenoid dermatitis, special forms of lichenoid dermatitis, lichenoid dermatitis in lupus erythematosus, and miscellaneous disorders showing lichenoid dermatitis, the salient clinical and histological features of which are described to facilitate their diagnosis. Background of lichenoid reaction pattern has been briefly outlined to enlighten those interested in this entity.
Topics: Animals; Dermatitis; Humans; Lichen Planus; Lichenoid Eruptions
PubMed: 21727689
DOI: 10.4103/0378-6323.82389 -
Ugeskrift For Laeger Dec 2018
Topics: Dermatitis; Diagnosis, Differential; Hemorrhage; Herpes Simplex; Humans
PubMed: 30618358
DOI: No ID Found -
British Medical Journal Jul 1964
Topics: Adrenal Cortex Hormones; Dermatitis, Atopic; Dermatitis, Contact; Dermatitis, Occupational; Detergents; Diagnosis; Eczema; Fluocinolone Acetonide; Hand Dermatoses; Humans; Keratosis; Nickel; Psychosomatic Medicine; Quaternary Ammonium Compounds; Tinea; Toxicology; Triamcinolone Acetonide; Water; Zinc
PubMed: 14150887
DOI: 10.1136/bmj.2.5402.151 -
International Archives of Occupational... Jan 2022Irritant contact dermatitis (ICD) is a major cause of occupational disease. The aim was to review the relation between exposure to occupational irritants and ICD and the... (Review)
Review
PURPOSE
Irritant contact dermatitis (ICD) is a major cause of occupational disease. The aim was to review the relation between exposure to occupational irritants and ICD and the prognosis of ICD.
METHODS
Through a systematic search, 1516 titles were identified, and 48 studies were included in the systematic review.
RESULTS
We found that the evidence for an association between ICD and occupational irritants was strong for wet work, moderate for detergents and non-alcoholic disinfectants, and strong for a combination. The highest quality studies provided limited evidence for an association with use of occlusive gloves without other exposures and moderate evidence with simultaneous exposure to other wet work irritants. The evidence for an association between minor ICD and exposure to metalworking fluids was moderate. Regarding mechanical exposures, the literature was scarce and the evidence limited. We found that the prognosis for complete healing of ICD is poor, but improves after decrease of exposure through change of occupation or work tasks. There was no substantial evidence for an influence of gender, age, or household exposures. Inclusion of atopic dermatitis in the analysis did not alter the risk of ICD. Studies were at risk of bias, mainly due to selection and misclassification of exposure and outcome. This may have attenuated the results.
CONCLUSION
This review reports strong evidence for an association between ICD and a combination of exposure to wet work and non-alcoholic disinfectants, moderate for metalworking fluids, limited for mechanical and glove exposure, and a strong evidence for a poor prognosis of ICD.
Topics: Dermatitis, Allergic Contact; Dermatitis, Atopic; Dermatitis, Irritant; Dermatitis, Occupational; Humans; Irritants; Occupational Exposure; Skin
PubMed: 34665298
DOI: 10.1007/s00420-021-01781-0 -
Dermatology (Basel, Switzerland) 2022Occupational contact dermatitis may progress to a chronic course with an unfavorable prognosis. Dupilumab has been shown to be effective as a treatment for...
BACKGROUND
Occupational contact dermatitis may progress to a chronic course with an unfavorable prognosis. Dupilumab has been shown to be effective as a treatment for moderate-to-severe atopic dermatitis as well as other types of dermatitis.
OBJECTIVES
The aim of the study was to describe cases of chronic recalcitrant occupational contact dermatitis treated with dupilumab and with long-term follow-up.
METHODS
A retrospective review of 6 patients treated with dupilumab for chronic occupational contact dermatitis for periods of up to 30 months was performed.
RESULTS
All 6 patients had a positive and sustainable response, with dermatitis clearance and the ability to sustain work tasks.
CONCLUSIONS
We report a case series of atopic and nonatopic workers with occupational chronic contact dermatitis who failed to achieve remission under various systemic modalities but did so using dupilumab. We suggest considering dupilumab treatment for recalcitrant occupational contact dermatitis.
Topics: Humans; Antibodies, Monoclonal, Humanized; Dermatitis, Atopic; Dermatitis, Allergic Contact; Dermatitis, Occupational; Chronic Disease; Treatment Outcome; Severity of Illness Index
PubMed: 35462358
DOI: 10.1159/000524380