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Der Hautarzt; Zeitschrift Fur... Jun 2021
Topics: Dermatitis, Occupational; Dermatology; Humans; Occupational Medicine
PubMed: 34061217
DOI: 10.1007/s00105-021-04823-3 -
The Journal of Investigative Dermatology Apr 2019Skin is colonized by microbial communities (microbiota) that participate in immune homeostasis, development and maintenance of barrier function, and protection from... (Review)
Review
Skin is colonized by microbial communities (microbiota) that participate in immune homeostasis, development and maintenance of barrier function, and protection from pathogens. The past decade has been marked by an increased interest in the skin microbiota and its role in cutaneous health and disease, in part due to advances in next-generation sequencing platforms that enable high-throughput, culture-independent detection of bacteria, fungi, and viruses. Various approaches, including bacterial 16S ribosomal RNA gene sequencing and metagenomic shotgun sequencing, have been applied to profile microbial communities colonizing healthy skin and diseased skin including atopic dermatitis, psoriasis, and acne, among others. Here, we provide an overview of culture-dependent and -independent approaches to profiling the skin microbiota and the types of questions that may be answered by each approach. We additionally highlight important study design considerations, selection of controls, interpretation of results, and limitations and challenges.
Topics: Bacteria; Biomedical Research; Dermatitis; High-Throughput Nucleotide Sequencing; Humans; Metagenome; Microbiota; Sequence Analysis, DNA; Skin
PubMed: 30904077
DOI: 10.1016/j.jid.2019.01.024 -
Indian Pediatrics Jun 2020
Topics: Dermatitis; Humans
PubMed: 32562410
DOI: No ID Found -
Australian Family Physician Sep 2006The intimate relationship of the skin and the mind illustrates the importance of a holistic approach in caring for patients with skin problems. Habits related to... (Review)
Review
BACKGROUND
The intimate relationship of the skin and the mind illustrates the importance of a holistic approach in caring for patients with skin problems. Habits related to psychological problems may lead to skin problems such as lichen simplex chronicus and acne excoriée. Emotional stress may affect skin diseases such as atopic dermatitis, perioral dermatitis, pompholyx, and plaque psoriasis.
OBJECTIVE
This article describes the relationship between the mind and skin disease.
DISCUSSION
Skin disease can exert a profound effect on the psychosocial dimension of a patient's life. Its effect on quality of life can be objectively assessed and documented by validated tools specific for the skin. Patient rated measures should be taken into account when evaluating the efficacy and adverse effects of treatments for skin disease.
Topics: Acne Vulgaris; Antipsychotic Agents; Dermatitis; Drug Eruptions; Humans; Mental Disorders; Neurodermatitis; Quality of Life; Skin Diseases; Stress, Psychological
PubMed: 16969446
DOI: No ID Found -
Journal of Immunology Research 2015Dendritic cells (DC) are professional antigen presenting cells and link the innate and adaptive immune system. During steady state immune surveillance in skin, DC act as... (Review)
Review
Dendritic cells (DC) are professional antigen presenting cells and link the innate and adaptive immune system. During steady state immune surveillance in skin, DC act as sentinels against commensals and invading pathogens. Under pathological skin conditions, inflammatory cytokines, secreted by surrounding keratinocytes, dermal fibroblasts, and immune cells, influence the activation and maturation of different DC populations including Langerhans cells (LC) and dermal DC. In this review we address critical differences in human DC subtypes during inflammatory settings compared to steady state. We also highlight the functional characteristics of human DC subsets in inflammatory skin environments and skin diseases including psoriasis and atopic dermatitis. Understanding the complex immunoregulatory role of distinct DC subsets in inflamed human skin will be a key element in developing novel strategies in anti-inflammatory therapy.
Topics: Animals; Cytokines; Dendritic Cells; Dermatitis; Humans; Immunomodulation; Inflammation; Inflammation Mediators
PubMed: 26229971
DOI: 10.1155/2015/743169 -
The Journal of Investigative Dermatology Jan 2021
Review
Topics: Celiac Disease; Child; Dermatitis Herpetiformis; Dermatitis, Atopic; Humans; Skin
PubMed: 32540248
DOI: 10.1016/j.jid.2020.05.091 -
The British Journal of Dermatology Dec 2022A high prevalence of skin sensitization and dermatitis has been reported among workers exposed to epoxy components.
BACKGROUND
A high prevalence of skin sensitization and dermatitis has been reported among workers exposed to epoxy components.
OBJECTIVES
To estimate the risk of skin sensitization and dermatitis among workers exposed to epoxy components during production of wind turbine blades while using comprehensive safety measures.
METHODS
A cross-sectional study of 180 highly epoxy-exposed production workers and 41 nonexposed office workers was conducted at two wind turbine blade factories in Denmark. Participants underwent a skin examination, were tested with a tailored patch test panel including epoxy-containing products used at the factories, and answered a questionnaire.
RESULTS
Sixteen production workers (8·9%) were sensitized to an epoxy component compared with none of the office workers. Skin sensitization was more frequent within the first year of exposed employment. Strong selection bias by atopic status was indicated. Among nonatopic workers, the prevalence of dermatitis was higher among production workers (16·4%) than among office workers [6·5%, odds ratio (OR) 2·3, 95% confidence interval (CI) 0·6-9·1] and higher among the sensitized workers (43·8%) than the nonsensitized workers (14·6%, OR 4·5, 95% CI 1·6-12·7). Resins based on diglycidyl ether of bisphenol A and F were the most frequent sensitizers. One of the four workers sensitized to epoxy components used at the factories did not react to the epoxy resin of the TRUE test panel.
CONCLUSIONS
Despite comprehensive skin protection, sensitization and dermatitis are prevalent among highly epoxy-exposed workers in the wind turbine industry in Denmark. Our findings document the need for intensified preventive efforts and emphasize the importance of tailored patch testing. What is already known about this topic? Epoxy components are well-known sensitizers of the skin. A high prevalence of skin sensitization and dermatitis has been reported among workers exposed to epoxy components. Comprehensive protective equipment is recommended when working with epoxy components. What does this study add? Despite comprehensive skin protection, skin sensitization and dermatitis are prevalent among epoxy-exposed workers. We found that 40% of workers sensitized to epoxy products had dermatitis. Only 75% of the sensitized workers were detected by the epoxy resin of the TRUE test , which emphasizes the importance of tailored testing.
Topics: Humans; Epoxy Resins; Dermatitis, Occupational; Dermatitis, Allergic Contact; Prevalence; Cross-Sectional Studies; Patch Tests
PubMed: 35972390
DOI: 10.1111/bjd.21830 -
Contact Dermatitis Mar 2023The objective of this review is to identify work-related and personal risk factors for contact dermatitis (CD), and assess their association with this frequently... (Meta-Analysis)
Meta-Analysis Review
The objective of this review is to identify work-related and personal risk factors for contact dermatitis (CD), and assess their association with this frequently occurring occupational disease. A systematic review of the literature from 1990 to June 2, 2020, was conducted using Medline and Embase. Prospective cohort and case-control studies were included, and meta-analyses were conducted when feasible. Quality of evidence was assessed using the Grading of Recommendations, Assessment, Development, and Evaluation. Twenty-nine studies were identified, comprising 26 study populations and with a total of 846 209 participants investigating 52 risk factors for CD. Meta-analyses were performed for five risk factors, all of them for irritant contact dermatitis (ICD). Moderate-quality evidence was found for associations between wet work and ICD (OR: 1.56, 95%CI: 1.21-2.01). High-quality evidence was found for the association between atopic dermatitis and ICD (OR: 2.44, 95%CI: 1.89-3.15). There was no evidence for an association between ICD and sex or history of hand dermatitis, respiratory and mucosal atopy. In conclusion, several work-related and personal risk factors associated with CD were identified. Our data emphasize the need for the assessment of both, work-related and personal, risk factors to prevent occupational CD.
Topics: Humans; Dermatitis, Allergic Contact; Prospective Studies; Dermatitis, Occupational; Dermatitis, Irritant; Risk Factors
PubMed: 36444496
DOI: 10.1111/cod.14253 -
Oncology (Williston Park, N.Y.) Dec 2017Radiation therapy (RT) is a frequently used modality for cancer treatment. Acute and/or chronic skin changes may occur and carry risk of influencing quality of life...
Radiation therapy (RT) is a frequently used modality for cancer treatment. Acute and/or chronic skin changes may occur and carry risk of influencing quality of life during and after completion of RT. Radiation reactions may lead to delays in treatment, diminished cosmesis, and functional deficits. Lifestyle factors, treatment modalities, topical agents, and, in some cases, wound dressings may be utilized to help prevent or ameliorate radiation-induced skin reactions. While rigorous evidence supporting specific interventions may be lacking or contradictory, this article summarizes the current knowledge of the etiology, manifestations, and interventions available for prevention and management of radiation dermatitis. Further well-designed studies are needed to confirm the efficacy of current recommendations and facilitate development of novel strategies for optimal care of patients with radiation dermatitis.
Topics: Humans; Radiodermatitis
PubMed: 29297172
DOI: No ID Found -
The Journal of Investigative Dermatology May 2021This review is intended to illuminate the emerging understanding of epigenetic modifications that regulate both adaptive and innate immunity in the skin. Host defense of... (Review)
Review
This review is intended to illuminate the emerging understanding of epigenetic modifications that regulate both adaptive and innate immunity in the skin. Host defense of the epidermis and dermis involves the interplay of many cell types to enable homeostasis; tolerance to the external environment; and appropriate response to transient microbial, chemical, and physical insults. To understand this process, the study of cutaneous immunology has focused on immune responses that reflect both adaptive learned and genetically programmed innate defense systems. However, recent advances have begun to reveal that epigenetic modifications of chromatin structure also have a major influence on the skin immune system. This deeper understanding of how enzymatic changes in chromatin structure can modify the skin immune system and may explain how environmental exposures during life, and the microbiome, lead to both short-term and long-term changes in cutaneous allergic and other inflammatory processes. Understanding the mechanisms responsible for alterations in gene and chromatin structure within skin immunocytes could provide key insights into the pathogenesis of inflammatory skin diseases that have thus far evaded understanding by dermatologists.
Topics: Dermatitis; Epigenesis, Genetic; Histones; Humans; Macrophages; Skin; T-Lymphocytes
PubMed: 33256976
DOI: 10.1016/j.jid.2020.10.012