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California Medicine Jul 1963Serum low-density lipoproteins of 12 hyperlipemic diabetic patients were lowered, in some cases to normal values, by administration of dextro-thyroxine. Accompanying...
Serum low-density lipoproteins of 12 hyperlipemic diabetic patients were lowered, in some cases to normal values, by administration of dextro-thyroxine. Accompanying reductions in serum total cholesterol were largely reflected in the low-density lipoprotein fraction. By contrast, high-density lipoprotein cholesterol concentrations remained relatively unchanged. Diabetic control by insulin or oral hypoglycemic agents was not detectably altered by dextro-thyroxine therapy for periods of 8 to 46 weeks. Therefore, use of the drug for treatment of diabetic hyperlipemia would appear to merit further investigation.
Topics: Cholesterol, HDL; Diabetes Mellitus; Diabetes Mellitus, Type 2; Humans; Hyperlipidemias; Hypoglycemic Agents; Insulin; Lipoproteins, HDL; Lipoproteins, LDL; Thyroxine
PubMed: 13987534
DOI: No ID Found -
Postgraduate Medical Journal Dec 1974Lowering of lipids in patients with chronic renal failure is advantageous but cannot be done by calorie restriction. In a controlled study the anabolic steroid... (Clinical Trial)
Clinical Trial
Lowering of lipids in patients with chronic renal failure is advantageous but cannot be done by calorie restriction. In a controlled study the anabolic steroid norethandrolone (Nilevar) was found to lower triglycerides by 50%, while D-thyroxine (Choloxin) lowered the cholesterol by 25%. Both drugs increased the activity of lipoprotein lipase in spite of uraemic inhibition. Norethandrolone also reduced basal serum insulin levels. Norethandrolone seems appropriate for underweight patients and D-thyroxine for overweight patients, but side effects are more frequent than in non-uraemic patients.
Topics: Dextrothyroxine; Drug Evaluation; England; Humans; Kidney Failure, Chronic; Lipids; Norethandrolone
PubMed: 4469041
DOI: 10.1136/pgmj.50.590.737 -
British Medical Journal Apr 1961
Topics: Dextrothyroxine; Exophthalmos; Humans; Hyperthyroidism; Thyrotoxicosis; Thyroxine
PubMed: 13682374
DOI: 10.1136/bmj.1.5234.1194 -
Canadian Medical Association Journal Nov 1961
Topics: Androgens; Androsterone; Arteriosclerosis; Atherosclerosis; Blood Coagulation; Blood Coagulation Factors; Cholesterol; Thyroxine
PubMed: 13888218
DOI: No ID Found -
British Medical Journal Jun 1961
Topics: Cholesterol; Dextrothyroxine; Humans; Thyroxine
PubMed: 13708306
DOI: 10.1136/bmj.1.5239.1572