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British Medical Journal May 1973
Topics: Animals; Cosmetics; Drug Compounding; Drug Eruptions; Humans; Lanolin; Sheep; Skin Tests
PubMed: 4267347
DOI: No ID Found -
Brazilian Journal of Biology = Revista... 2021Alo vera is a centenary remedy use for minor wounds and burns, but its mechanism of wound healing has not been know since. This article will evaluate and gather evidence...
Alo vera is a centenary remedy use for minor wounds and burns, but its mechanism of wound healing has not been know since. This article will evaluate and gather evidence of the effectiveness and safety of the use of aloe vera in the treatment of burns. A systematic review was carried out on the databases: MEDLINE, LILACS, DECS, SCIELO, in the last 7 years, with the descriptors: "Aloe", "Burns" and "treatment". 16 articles were found. After using the exclusion criteria; research in non-humans and literature review; 5 articles were selected. The article Teplick et al. (2018) performed an in vitro clinical experiment in A. Vera solution, and demonstrated that there was proliferation and cell migration of human skin fibroblasts and keratinocytes, in addition to being protective in the death of keratonocytes. That is, it accelerates the healing of wounds. Muangman et al. (2016), evaluated 50 patients with 20% of the total body surface area burned with second-degree burns, between 18-60 years old, with half of the group receiving gauze dressings with soft paraffin containing 0.5% chlorhexidine acetate and the other half receiving polyester dressings containing extracts of medicinal plants mainly Aloe Vera. It had positive results, a higher healing speed and shorter hospital stay compared to the control group. Hwang et al. (2015) investigated the antioxidant effects of different extracts from 2,4,6,8,12 months of Aloe Vera. And the 6-month concentrated extract of 0.25 mg / mL had a higher content of flavonoids (9.750 mg catechin equivalent / g extract) and polyphenols (23.375 mg gallic acid equivalent / g extract) and the greater ferric reducing antioxidant power (0.047 mM equivalent ferrous sulfate / mg extract), that is, greater potential for free radical scavenging and also a protective effect against oxidative stress induced by tert-butyl hydroperoxide (t-BHP), suggesting evidence of a bioactive potential of A. vera . However, in the article Kolacz et al. (2014) suggested as an alternative treatment the use of Aloe Vera dressing in combination with honey, lanolin, olive oil, wheat germ oil, marshmallow root, wormwood, comfrey root, white oak bark, lobelia inflata, glycerin vegetable oil, beeswax and myrrh, without obtaining significant and conclusive results that would allow the conventional treatment of burns to be subsidized. Finally, in the article by Zurita and Gallegos (2017), it carried out a descriptive cross-sectional study with 321 people, both sexes between 17-76 years of age, of an inductive nature, exploring the experience of this population and their behavioral attitudes regarding the treatment of dermatoses. Aloe vera had 13.8% cited by individuals in the treatment of acne and 33.6% in the treatment of burns. Even with evidence that suggests the efficacy in the treatment of burns with the use of Aloe Vera extract, further clinical trials with larger sample space on the use of Aloe vera dressings in medium burns are suggested for further conclusions.
Topics: Aloe; Burns; Cross-Sectional Studies; Humans; Plant Extracts; Plants, Medicinal; Wound Healing
PubMed: 34550291
DOI: 10.1590/1519-6984.249209 -
European Radiology Experimental Mar 2019Externally controlling and monitoring drug release at a desired time and location is currently lacking in the gastrointestinal tract. The aim of the study was to develop...
BACKGROUND
Externally controlling and monitoring drug release at a desired time and location is currently lacking in the gastrointestinal tract. The aim of the study was to develop a thermoresponsive wax-coated capsule and to trigger its release upon applying a magnetic resonance imaging (MRI)-guided high-intensity focused ultrasound (HIFU) pulse.
METHODS
Capsules containing a lyophilised gadolinium-based contrast agent (GBCA) were coated with a 1:1 (mass/mass) mixture of lanolin and cetyl alcohol (melting point ≈43 °C) and exposed to simulated gastric and intestinal fluids (United States Pharmacopoeia) at 37 °C for 2 and 24 h, respectively. In a HIFU gel phantom, wax-coated capsules (n = 3) were tracked based on their T1- and T2-hypointensity by 1.5-T T1- and T2-weighted MRI pre- and post-exposure to an MRI-guided HIFU pulse.
RESULTS
Lanolin/cetyl alcohol-coated capsules showed high resistance to simulated gastrointestinal fluids. In a gel phantom, an MRI-guided HIFU pulse punctured the wax coating, resulting in the hydration and release of the encapsulated lyophilised GBCA and yielding a T1-hyperintense signal close to the wax-coated capsule.
CONCLUSION
We provide the proof-of-concept of applying a non-invasive MRI-guided HIFU pulse to actively induce the disintegration of the wax-coated capsule, and a method to monitor the release of the cargo via T1-weighted MRI based on the hydration of an encapsulated lyophilised GBCA. The wax-coated capsule platform enables temporally and spatially supertargeted drug release via the oral route and promises to address a currently unmet clinical need for personalised local therapy in gastrointestinal diseases such as inflammatory bowel diseases and cancer.
PubMed: 30838465
DOI: 10.1186/s41747-019-0090-9 -
Biomolecules Feb 2020Anthocyanin contributes to the coloration of pear fruit and enhances plant defenses. Members of the ethylene response factor (ERF) family play vital roles in hormone and...
Anthocyanin contributes to the coloration of pear fruit and enhances plant defenses. Members of the ethylene response factor (ERF) family play vital roles in hormone and stress signaling and are involved in anthocyanin biosynthesis. Here, was identified from the lanolin-induced red fruit of 'Zaosu' pear ( Rehd.) using a comparative transcriptome analysis. Its expression level was up- and down-regulated by methyl jasmonate and 1-methylcyclopropene plus lanolin treatments, respectively, which indicated that responded to the jasmonate- and ethylene-signaling pathways. In addition, transiently overexpressed induced anthocyanin biosynthesis in 'Zaosu' fruit, and a quantitative PCR analysis further confirmed that facilitated the expression of anthocyanin biosynthetic structural and regulatory genes. Moreover, a dual luciferase assay showed that enhanced the activation effects of and on the promoter. Therefore, responses to jasmonate and ethylene signals and regulates anthocyanin biosynthesis. This provides a new perspective on the correlation between jasmonate-ethylene crosstalk and anthocyanin biosynthesis.
Topics: Acetates; Anthocyanins; Color; Cyclopentanes; DNA, Plant; DNA-Binding Proteins; Ethylenes; Fruit; Gene Expression Regulation, Plant; Genes, Regulator; Lanolin; Oxylipins; Plant Growth Regulators; Plant Proteins; Promoter Regions, Genetic; Pyrus; Transcriptome; Up-Regulation
PubMed: 32054132
DOI: 10.3390/biom10020278 -
Ulusal Travma Ve Acil Cerrahi Dergisi =... Mar 2020Studies evaluating the recovery of the zone of stasis is an important issue in burn research. In this study, we aimed to evaluate and compare the efficiency of an...
BACKGROUND
Studies evaluating the recovery of the zone of stasis is an important issue in burn research. In this study, we aimed to evaluate and compare the efficiency of an anti-ischemic and vasodilatory agent, a topical agent containing 2% nitroglycerin with 1% silver sulfadiazine, and bacitracin-neomycin sulfate in the zone of stasis histomorphologically and immunohistochemically.
METHODS
We conducted an experimental study using 30 Wistar-Albino rats, each weighing 250-300 grams. The rats were divided randomly into five groups (six rats in each group). In this study, the "comb model," which was deemed to be the most appropriate experimental model to produce an injury with predictable zones and was first described by Regas and Erhlich, was used. The following were applied to the zone of stasis after creating a burn model in 0, 24, and 48 hours: topical 2% nitroglycerin, 1% silver sulfadiazine, bacitracin-neomycin sulfate, and Vaseline-lanolin (sham). After 72 hours, biopsies were performed from the zone of stasis and evaluated by histomorphological and immunohistochemical CD 34 (expressed in human endothelial and hematopoietic cells) and D 2-40 (expressed in the endothelium of lymphatic capillaries) methods. The results were evaluated using the chi-square test.
RESULTS
Compared with the other groups, a statistically significant difference was found in edema, inflammation, and vascular proliferation in the nitroglycerin group. Significantly more intense staining for CD 34 was found in the nitroglycerin group compared with the other groups. Immunohistochemical staining for D 2-40 was also found statistically significant in the nitroglycerin group (p<0.05).
CONCLUSION
A topical containing 2% nitroglycerin increases vascular proliferation in the zone of stasis affects the recovery and may be used as a new agent in burn injury treatment.
Topics: Animals; Burns; Disease Models, Animal; Edema; Inflammation; Male; Nitroglycerin; Rats; Silver Sulfadiazine; Skin
PubMed: 32185753
DOI: 10.14744/tjtes.2019.00005 -
The Book & Paper Group Annual 2017The application of oil-based leather dressing, while once considered a best practice in libraries, led to undesirable long-term consequences for bound materials. At the...
The application of oil-based leather dressing, while once considered a best practice in libraries, led to undesirable long-term consequences for bound materials. At the National Institutes of Health (NIH) in the National Library of Medicine (NLM), many leather-bound volumes had multiple applications of a mixture of neatsfoot oil and lanolin dressings liberally applied. The oils not only absorbed into the leather bindings but also migrated onto the pastedowns, end sheets, gutters, and text blocks. The oiling process at NLM was documented by call number, year(s), number of applications, and dressing formula. While investigating treatment options, the NLM senior conservator consulted a paintings and objects conservator for insight on viable options for the removal of oil from artifacts. An art-on-paper conservator joined the collaborative effort to develop a treatment protocol for NLM's oil saturated collections. Together, they investigated the issue and devised an effective method for removal of this oil from the NIH collection materials. The protocol involves washing with an alkaline solution followed by alternating applications of petroleum ether and acetone applied either over suction or by immersion. Oil components are solubilized by the alternating polarities of the solvents and then removed from the paper using suction or immersion. After the oil is removed, the paper is washed again with alkaline water to remove any remaining water soluble discoloration. This article will explore further details of the treatment protocol, its development and applications, and the benefits of cross-disciplinary collaboration.
PubMed: 29630074
DOI: No ID Found -
Skin Appendage Disorders Jan 2021Excess hair is a problem for both men and women who want to conform to today's cosmetic social norms. Chemical depilatories are a safe, fast, and inexpensive method of...
Excess hair is a problem for both men and women who want to conform to today's cosmetic social norms. Chemical depilatories are a safe, fast, and inexpensive method of hair removal. The most commonly used depilatory agents are thioglycolates and to a lesser extent, sulphides. The most common side effect of chemical depilatories is irritant contact dermatitis. However, allergic contact dermatitis is rare and may be related to lanolin, fragrance, or thioglycolate itself. Unilateral koilonychia as a side effect of chemical depilatories has not been described previously in the literature. We report this case due to its rarity and highlight the significance of nail protection while using chemical depilatory products.
PubMed: 33614715
DOI: 10.1159/000510523 -
Journal of Applied Oral Science :... 2013The side effects of chemotherapy on the lips may cause esthetic and functional impact and increase the risk of infection. HPA Lanolin® is an option for supportive...
UNLABELLED
The side effects of chemotherapy on the lips may cause esthetic and functional impact and increase the risk of infection. HPA Lanolin® is an option for supportive therapy because it has anti-inflammatory, antimicrobial and moisturizing properties.
OBJECTIVE
To evaluate the efficacy of this product in the prevention of lip alterations in a population of patients undergoing chemotherapy.
MATERIAL AND METHODS
Patients undergoing chemotherapy (n = 57) were examined and distributed into two groups: study (used HPA Lanolin®) and control (without supportive therapy on the lips). We evaluated the patients two weeks after chemotherapy, registering oral alterations, symptoms of pain, discomfort, limitation of mouth opening and dehydration, classified according to a visual analogue scale.
RESULTS
Patients who used HPA Lanolin® had lower dehydration and experienced improvement of lip dryness (p<0.001). The main symptoms were dehydration, discomfort, limitation of mouth opening, pain. The main clinical signs were dry lips, mucositis, cheilitis, hematoma, swelling and cracking. We found no difference concerning the variables of pain, discomfort, and limitation of mouth opening between the study and control group.
CONCLUSIONS
We suggest that HPA Lanolin® is effective in reducing the symptoms of dehydration and the signs of lip dryness resulting from toxicity of chemotherapy, proving to be an interesting alternative supportive therapy for cancer patients.
Topics: Adolescent; Adult; Antineoplastic Agents; Cosmetics; Dehydration; Female; Humans; Lanolin; Lip; Male; Mucositis; Neoplasms; Pain; Pain Measurement; Prospective Studies; Statistics, Nonparametric; Time Factors; Treatment Outcome; Young Adult
PubMed: 23739860
DOI: 10.1590/1678-7757201302308 -
PloS One 2020Healthcare workers around the world are experiencing skin injury due to the extended use of personal protective equipment (PPE) during the COVID-19 pandemic. These...
BACKGROUND
Healthcare workers around the world are experiencing skin injury due to the extended use of personal protective equipment (PPE) during the COVID-19 pandemic. These injuries are the result of high shear stresses acting on the skin, caused by friction with the PPE. This study aims to provide a practical lubricating solution for frontline medical staff working a 4+ hours shift wearing PPE.
METHODS
A literature review into skin friction and skin lubrication was conducted to identify products and substances that can reduce friction. We evaluated the lubricating performance of commercially available products in vivo using a custom-built tribometer.
FINDINGS
Most lubricants provide a strong initial friction reduction, but only few products provide lubrication that lasts for four hours. The response of skin to friction is a complex interplay between the lubricating properties and durability of the film deposited on the surface and the response of skin to the lubricating substance, which include epidermal absorption, occlusion, and water retention.
INTERPRETATION
Talcum powder, a petrolatum-lanolin mixture, and a coconut oil-cocoa butter-beeswax mixture showed excellent long-lasting low friction. Moisturising the skin results in excessive friction, and the use of products that are aimed at 'moisturising without leaving a non-greasy feel' should be prevented. Most investigated dressings also demonstrate excellent performance.
Topics: Adult; Betacoronavirus; Biomechanical Phenomena; COVID-19; Coronavirus Infections; Friction; Humans; Lubricants; Male; Medical Staff; Pandemics; Personal Protective Equipment; Pneumonia, Viral; SARS-CoV-2; Skin
PubMed: 32970710
DOI: 10.1371/journal.pone.0239363 -
Maternal & Child Nutrition Jul 2017Nipple pain and damage are commonly experienced by breastfeeding women and are associated with negative breastfeeding outcomes. Health care providers often recommend the... (Randomized Controlled Trial)
Randomized Controlled Trial
Nipple pain and damage are commonly experienced by breastfeeding women and are associated with negative breastfeeding outcomes. Health care providers often recommend the application of lanolin to treat painful/damaged nipples, yet no randomized controlled trial has evaluated the effectiveness of lanolin on nipple pain and breastfeeding outcomes. The purpose of this study was to evaluate the effect of lanolin on nipple pain among breastfeeding women with damaged nipples. A randomized, single-blind, controlled trial was conducted at a tertiary care hospital in Hamilton, Ontario, Canada. Breastfeeding women (N = 186) identified as having nipple pain/damage were randomized to apply lanolin (intervention group; n = 93) or to receive usual postpartum care (control group; n = 93). The primary outcome was nipple pain at 4 days post-randomization measured by the Numeric Rating Scale. Additional outcomes included nipple pain measured by the Short Form McGill Pain Questionnaire, breastfeeding duration/exclusivity, breastfeeding self-efficacy, and maternal satisfaction with lanolin treatment versus usual care. The results revealed no significant group differences in mean pain scores at 4 days post-randomization. Women in both groups experienced clinically relevant decreases in nipple pain by 7 days post-randomization. Significantly, more women in the lanolin group reported that they were satisfied with treatment compared with those receiving usual care. No significant group differences were found for other secondary outcomes. While more women were satisfied using lanolin, its application to sore/damaged nipples was ineffective for reducing nipple pain or improving breastfeeding outcomes.
Topics: Adult; Breast Feeding; Canada; Cosmetics; Female; Humans; Lanolin; Nipples; Pain; Pain Management; Sample Size; Single-Blind Method; Socioeconomic Factors; Treatment Outcome; Young Adult
PubMed: 27477840
DOI: 10.1111/mcn.12357