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Methamphetamine-induced behavioral alterations following repeated administration of methamphetamine.Japanese Journal of Pharmacology Jun 1986Repeated administration of a large dose of methamphetamine (MA) (25 mg/kg, i.p. twice daily for 4 days) to mice enhanced locomotor activity and decreased stereotyped...
Repeated administration of a large dose of methamphetamine (MA) (25 mg/kg, i.p. twice daily for 4 days) to mice enhanced locomotor activity and decreased stereotyped behavior following a subsequent injection of MA. Simultaneous determinations of catecholamines revealed a depletion of brain dopamine. The moderate doses of haloperidol significantly enhanced MA-induced locomotor activity in mice. A significant enhancement of MA-induced locomotor activity was observed in the rats pretreated with 6-hydroxydopamine into the striatum, and this effect correlated negatively with the striatal dopamine level. These results suggest that hypofunction of striatal dopaminergic neuron systems induced by repeated administration of MA may be one of possible mechanisms of the enhancement of MA-induced locomotor activity due to the decrease of stereotyped behavior.
Topics: Animals; Brain Chemistry; Catecholamines; Corpus Striatum; Drug Interactions; Haloperidol; Hydroxydopamines; Injections; Male; Methamphetamine; Methotrimeprazine; Mice; Motor Activity; Oxidopamine; Stereotyped Behavior
PubMed: 3091891
DOI: 10.1254/jjp.41.147 -
In Vivo (Athens, Greece) 2005The ability of phenothiazine derivatives to inhibit the transport activity of P-glycoprotein in resistant mouse lymphoma and MDR/COLO 320 cells was studied. A rhodamine... (Comparative Study)
Comparative Study
The ability of phenothiazine derivatives to inhibit the transport activity of P-glycoprotein in resistant mouse lymphoma and MDR/COLO 320 cells was studied. A rhodamine 123 efflux from the above-mentioned neoplastic cells in the presence of tested compounds was examined by flow cytometry. Two of the phenothiazine derivatives, namely perphenazine and prochlorperazine dimaleate, proved to be effective inhibitors of the rhodamine efflux. Other tested phenothiazine derivatives (promethazine hydrochloride, oxomemazine, methotrimeprazine maleate, trifluoropromazine hydrochloride, trimeprazine) also modulated the intracellular drug accumulation in both resistant cell lines, however, they exerted additional cytotoxic effects. The differences observed between the effects of the test compounds on intracellular drug accumulation could be the outcome of differences in phenothiazine's chemical structure, which is crucial for drug-cell membrane interactions. The results of this study provide information about a new group of compounds that offer promise in multidrug resistance reversal in tumor cells.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Animals; Biological Transport; Cell Line, Tumor; Colonic Neoplasms; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Flow Cytometry; Fluorescent Dyes; Genes, MDR; Humans; Lymphoma, T-Cell; Mice; Molecular Structure; Perphenazine; Phenothiazines; Prochlorperazine; Rhodamines
PubMed: 16277030
DOI: No ID Found -
British Journal of Pharmacology Mar 19741 The relative potencies of methotrimeprazine, (+)-methotrimeprazine, (+/-)-10-(3-dimethylamino-2-methylpropyl)-2-valeroyl phenothiazine hydrochloride (M & B 18,706) and... (Comparative Study)
Comparative Study
1 The relative potencies of methotrimeprazine, (+)-methotrimeprazine, (+/-)-10-(3-dimethylamino-2-methylpropyl)-2-valeroyl phenothiazine hydrochloride (M & B 18,706) and (+)-M & B 18,706 in reducing the pressor action of noradrenaline in the spinal cat, reducing intercollicular decerebrate rigidity, and muscle spindle afferent activity have been studied.2 Methotrimeprazine was eight times as potent as (+)-methotrimeprazine in reducing the pressor action of noradrenaline and six times as potent in reducing decerebrate rigidity. M & B 18,706 was also eight times as potent as (+)-M & B 18,706 in reducing the pressor action of noradrenaline and six times as potent in reducing decerebrate rigidity.3 For the above compounds and chlorpromazine there was a significant correlation between the effective doses for the inhibition of the pressor action of noradrenaline and for the reduction of decerebrate rigidity.4 The doses which reduced decerebrate rigidity were similar to those that reduced muscle spindle afferent discharge. It is likely that these drugs reduce decerebrate rigidity by inhibiting fusimotor activity.5 Desipramine increased decerebrate rigidity and increased spindle afferent discharge.6 It is thought that the phenothiazine derivatives studied reduce decerebrate rigidity and spindle afferent discharge by inhibiting receptors for noradrenaline in the central nervous system.
Topics: Animals; Blood Pressure; Cats; Chlorpromazine; Decerebrate State; Desipramine; Dimethylamines; Dose-Response Relationship, Drug; Methotrimeprazine; Muscle Rigidity; Muscle Spindles; Nictitating Membrane; Norepinephrine; Phenothiazines; Receptors, Adrenergic; Serotonin Antagonists; Structure-Activity Relationship; Valerates
PubMed: 4277330
DOI: 10.1111/j.1476-5381.1974.tb09610.x -
Japanese Journal of Pharmacology Apr 1972
Comparative Study
Topics: Acoustic Stimulation; Analgesics; Animals; Arousal; Brain; Chlorpromazine; Dental Pulp; Electric Stimulation; Electroencephalography; Female; Hippocampus; Male; Methotrimeprazine; Morphine; Motor Cortex; Physical Stimulation; Rabbits; Sciatic Nerve; Somatosensory Cortex
PubMed: 4538418
DOI: 10.1254/jjp.22.264 -
Psychogeriatrics : the Official Journal... Mar 2012Herein we report the case of a 77-year-old, right-handed man, without dementia, who had a cerebral infarction in the left caudate head that manifested recurrent...
Herein we report the case of a 77-year-old, right-handed man, without dementia, who had a cerebral infarction in the left caudate head that manifested recurrent delusional ideas. He experienced three episodes of delusional ideas; the first two occurred after loss of consciousness and the third after delirium at night. MRI findings of left caudate head infarction were the same for all three episodes. An unstable cerebral perfusion may have caused problems in the cerebral network between the caudate head and cerebral cortex. Decreased cerebral blood flow in the frontal lobe was noted particularly in the second and third episodes, supporting the neurological background of disinhibition of emotional behaviour. Antipsychotic drugs and a small dose of risperidone were effective in controlling the patient's delusional ideas.
Topics: Aged; Antipsychotic Agents; Brain; Cerebral Infarction; Cerebrovascular Circulation; Delusions; Dementia; Follow-Up Studies; Humans; Magnetic Resonance Imaging; Male; Methotrimeprazine; Recurrence; Risperidone; Tomography, Emission-Computed, Single-Photon
PubMed: 22416830
DOI: 10.1111/j.1479-8301.2011.00385.x -
British Journal of Pharmacology and... Mar 1958Of the substances studied for their inhibitory action of the oedema formation in the hind-paw of the rat, the most active was a new derivative of phenothiazine, related...
Of the substances studied for their inhibitory action of the oedema formation in the hind-paw of the rat, the most active was a new derivative of phenothiazine, related to chlorpromazine. It is methotrimeprazine {10-(3-dimethylamino-2-methylpropyl)-2-methoxyphenothiazine; 7044 RP}. This substance possesses potent antihistamine and anti-5-hydroxytryptamine properties, and doses of 0.25 mg./kg. inhibited the blueing and swelling of the foot after injections of histamine, 5-hydroxytryptamine, eggwhite, dextran or compound 48/80 into the feet of rats with sulphan blue (Evan's blue) dye in their circulation. The results indicate that both histamine and 5-hydroxytryptamine play rôles in increasing capillary permeability in the rat.
Topics: Animals; Capillary Permeability; Dextrans; Edema; Histamine; Histamine H1 Antagonists; Phenothiazines; Rats; Serotonin; p-Methoxy-N-methylphenethylamine
PubMed: 13523137
DOI: 10.1111/j.1476-5381.1958.tb00192.x -
British Medical Journal Aug 1976
Topics: Acepromazine; Drug Combinations; Etorphine; Humans; Methotrimeprazine; Morphinans; Narcotic Antagonists; Poisoning
PubMed: 953617
DOI: 10.1136/bmj.2.6033.472-c -
Anaesthesia Oct 1983Release of hormones peri-operatively in patients with metastatic carcinoids may lead to severe circulatory and respiratory disturbances. Fourteen patients with liver...
Release of hormones peri-operatively in patients with metastatic carcinoids may lead to severe circulatory and respiratory disturbances. Fourteen patients with liver metastases were studied during 16 operations with a modified neurolept anaesthesia in order to evaluate the central haemodynamic and respiratory functions as well as plasma serotonin levels. The premedication in five patients was supplemented with levopromazine. During the 11 operations performed on patients not pretreated with levopromazine, no major significant fluctuations in circulatory or respiratory functions were recorded although big variations in serotonin plasma levels were measured. In the patients treated with levopromazine, however, significant changes were observed in heart rate, mean pulmonary artery pressure, cardiac index, and left and right ventricular stroke work especially during flushing episodes. However, these changes did not correlate with the changes in plasma serotonin levels. Modified neurolept anaesthesia without levopromazine pretreatment combined with careful monitoring seems to be a safe procedure for carcinoid patients. Using this type of anaesthetic procedure only one major complication occurred in connexion with 16 major operations and then in the postoperative period.
Topics: Adult; Aged; Droperidol; Female; Fentanyl; Hemodynamics; Humans; Intraoperative Period; Male; Malignant Carcinoid Syndrome; Methotrimeprazine; Middle Aged; Monitoring, Physiologic; Neuroleptanalgesia; Preanesthetic Medication; Respiration; Serotonin
PubMed: 6638441
DOI: 10.1111/j.1365-2044.1983.tb12026.x -
Agranulocytosis associated with methotrimeprazine (Nozinan) administration: a report of three cases.Canadian Medical Association Journal Jun 1970
Topics: Adult; Agranulocytosis; Female; Humans; Male; Methotrimeprazine
PubMed: 5445698
DOI: No ID Found -
Japanese Journal of Pharmacology Aug 1974
Topics: Amitriptyline; Animals; Behavior, Animal; Chlordiazepoxide; Chlorpromazine; Depression, Chemical; Diazepam; Dose-Response Relationship, Drug; Electric Stimulation; Electrodes, Implanted; Haloperidol; Hypothalamus; Imipramine; Male; Methamphetamine; Methotrimeprazine; Motor Activity; Motor Skills; Pentobarbital; Psychotropic Drugs; Rats; Self Stimulation; Stimulation, Chemical; Tranquilizing Agents
PubMed: 4455970
DOI: 10.1254/jjp.24.613