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Japanese Journal of Pharmacology Aug 1974
Topics: Amitriptyline; Animals; Behavior, Animal; Chlordiazepoxide; Chlorpromazine; Depression, Chemical; Diazepam; Dose-Response Relationship, Drug; Electric Stimulation; Electrodes, Implanted; Haloperidol; Hypothalamus; Imipramine; Male; Methamphetamine; Methotrimeprazine; Motor Activity; Motor Skills; Pentobarbital; Psychotropic Drugs; Rats; Self Stimulation; Stimulation, Chemical; Tranquilizing Agents
PubMed: 4455970
DOI: 10.1254/jjp.24.613 -
Internal Medicine (Tokyo, Japan) May 2001
Topics: Adult; Anticonvulsants; Carbamazepine; Drinking; Humans; Hyponatremia; Inappropriate ADH Syndrome; Male; Methotrimeprazine
PubMed: 11393424
DOI: 10.2169/internalmedicine.40.459 -
Actas Dermo-sifiliograficas 2015
Topics: Brain Injuries, Traumatic; Cheilitis; Chlorpromazine; Dermatitis, Photoallergic; Dopamine Antagonists; Drug Substitution; Eyelid Diseases; Female; Hand Dermatoses; Humans; Irritable Bowel Syndrome; Methotrimeprazine; Middle Aged; Patch Tests
PubMed: 25704376
DOI: 10.1016/j.ad.2014.12.006 -
British Journal of Pharmacology and... Jun 1961Although chlorpromazine and acepromazine were the most potent suppressants of local tetanus induced in rabbits by intramuscular injection of the toxin of Cl. tetani,...
Although chlorpromazine and acepromazine were the most potent suppressants of local tetanus induced in rabbits by intramuscular injection of the toxin of Cl. tetani, repeated injections lost their effect (tachyphylaxis) and sometimes even increased muscle activity, as did single large injections of either of the two drugs. As neither tachyphylaxis nor stimulation occurred in spinal animals, these effects might arise from an action in the brain-stem reticular formation on which chlorpromazine has been shown to have both inhibitory and excitatory effects. The possible cause of the tachyphylaxis is discussed. Evidence is advanced to support the view that tachyphylaxis can occur when chlorpromazine is used in the treatment of tetanus in man. Methotrimeprazine was more potent than chlorpromazine, but less prone to induce tachyphylaxis. These qualities rendered it more desirable for clinical use than the other two compounds.
Topics: Animals; Chlorpromazine; Humans; Male; Methotrimeprazine; Phenothiazines; Rabbits; Tachyphylaxis; Tetanus; Tetanus Toxoid; Tranquilizing Agents
PubMed: 13759492
DOI: 10.1111/j.1476-5381.1961.tb01088.x -
Anesthesiology 1964
Topics: Biomedical Research; Blood Circulation; Blood Pressure; Blood Pressure Determination; Methotrimeprazine; Morphine; Pharmacology; Posture; Preanesthetic Medication; Syncope; Toxicology
PubMed: 14211495
DOI: 10.1097/00000542-196409000-00014 -
British Journal of Clinical Pharmacology Oct 1990The in vivo inhibitory effect of five beta-adrenoceptor antagonists and levomepromazine on debrisoquine metabolism was assessed in 37 subjects. The debrisoquine...
The in vivo inhibitory effect of five beta-adrenoceptor antagonists and levomepromazine on debrisoquine metabolism was assessed in 37 subjects. The debrisoquine phenotyping test was performed before and after 7 days' treatment with oxprenolol (40 mg three times daily), propranolol (20 mg three times daily), timolol (10 mg twice daily), pindolol (5 mg twice daily), metoprolol (50 mg twice daily) or levomepromazine (10 mg daily), each of which was given to six-seven subjects. No clear change in the urinary metabolic ratio of debrisoquine/4-OH-debrisoquine (MR) was seen with any of the single beta-adrenoceptor antagonist treatments, but the MR value increased significantly when all beta-adrenoceptor blocker treatments were considered together. Debrisoquine metabolism was clearly impaired after levomepromazine 10 mg daily for 7 days; the mean MR increased from 1.24 +/- 1.6 to 4.70 +/- 5.23 (P = 0.018) and the excretion of 4-hydroxydebrisoquine decreased from 0.92 +/- 0.46 mg to 0.31 +/- 0.19 mg (P = 0.043). Thus, levomepromazine changes MRs towards those characteristic of phenotypically poor metabolizers, but beta-adrenoceptor antagonists at the doses examined have only a marginal effect.
Topics: Adrenergic beta-Antagonists; Adult; Debrisoquin; Female; Humans; Male; Methotrimeprazine
PubMed: 1981321
DOI: 10.1111/j.1365-2125.1990.tb03827.x -
The Journal of Physiology Apr 1972
Topics: Animals; Cats; Decerebrate State; Desipramine; Methotrimeprazine; Moxisylyte; Muscle Spindles; Neurons, Afferent; Norepinephrine; Phenothiazines; Receptors, Adrenergic; Receptors, Drug
PubMed: 4260733
DOI: No ID Found -
The Tohoku Journal of Experimental... Feb 1965
Topics: Avoidance Learning; Chlorpromazine; Methotrimeprazine; Perphenazine; Phenothiazines; Prochlorperazine; Promazine; Psychopharmacology; Rats; Research; Tranquilizing Agents; Trifluoperazine; Triflupromazine; Trimeprazine
PubMed: 14285070
DOI: 10.1620/tjem.85.83 -
Anesthesiology 1963
Topics: Methotrimeprazine; Respiratory Function Tests; Tranquilizing Agents
PubMed: 13942260
DOI: 10.1097/00000542-196301000-00006 -
Journal of Neurology, Neurosurgery, and... Jun 1999
Topics: Aged; Creutzfeldt-Jakob Syndrome; Electroencephalography; Female; Humans; Lithium; Male; Methotrimeprazine; Phenobarbital
PubMed: 10400510
DOI: 10.1136/jnnp.66.6.802