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BMJ Case Reports Nov 2021
Topics: Humans; Meningitis, Viral; Meningoencephalitis; Mumps
PubMed: 34764134
DOI: 10.1136/bcr-2021-247306 -
BMJ Case Reports Mar 2019A 43-year-old previously healthy man presented to the primary care clinic with concurrent ipsilateral viral parotitis and herpes zoster ophthalmicus. The patient...
A 43-year-old previously healthy man presented to the primary care clinic with concurrent ipsilateral viral parotitis and herpes zoster ophthalmicus. The patient experienced painful swelling below the right ear as well as painful vesicles on the right forehead, eyelid and cheek in the V1 dermatomal region. There were no lesions in the oral cavity or nose. Antibody titres confirmed active varicella zoster virus in the absence of mumps or herpes simplex virus 1 and 2 and unilateral parotitis were confirmed to be non-suppurative by the patient's primary care physician and the neurologist. Both conditions resolved within 3 weeks with appropriate treatment.
Topics: Adult; Antiviral Agents; Herpes Zoster Ophthalmicus; Herpesvirus 3, Human; Humans; Male; Parotitis; Valacyclovir
PubMed: 30898945
DOI: 10.1136/bcr-2018-228897 -
BMJ Case Reports Feb 2021
Topics: Bell Palsy; Facial Nerve; Facial Paralysis; Humans; Parotitis
PubMed: 33541969
DOI: 10.1136/bcr-2020-241001 -
Journal of Clinical Microbiology Jan 2022Since 2015, the United States has experienced a resurgence in the number of mumps cases and outbreaks in fully vaccinated populations. These outbreaks have occurred...
Since 2015, the United States has experienced a resurgence in the number of mumps cases and outbreaks in fully vaccinated populations. These outbreaks have occurred predominantly in close-quarter settings, such as camps, colleges, and detention centers. Phylogenetic analysis of 758 mumps-positive samples from outbreaks across the United States identified 743 (98%) as genotype G based on sequence analysis of the mumps small hydrophobic (SH) gene. Additionally, SH sequences in the genotype G samples showed almost no sequence diversity, with 675 (91%) of them having identical sequences or only one nucleotide difference. This uniformity of circulating genotype and strain created complications for epidemiologic investigations and necessitated the development of a system for rapidly generating mumps whole-genome sequences for more detailed analysis. In this study, we report a novel and streamlined assay for whole-genome sequencing (WGS) of mumps virus genotype G. The WGS procedure successfully generated 318 high-quality WGS sequences on nucleic acid from genotype G-positive respiratory samples collected during several mumps outbreaks in the United States between 2016 and 2019. Sequencing was performed by a rapid and highly sensitive custom Ion AmpliSeq mumps genotype G panel, with sample preparation performed on an Ion Chef and sequencing on an Ion S5. The WGS data generated by the AmpliSeq panel provided enhanced genomic resolution for epidemiological outbreak investigations. Translation and protein sequence analysis also identified several potentially important epitope changes in the circulating mumps genotype G strains compared to the Jeryl-Lynn strain (JL5) used in vaccines in the United States, which could explain the current level of vaccine escapes.
Topics: Disease Outbreaks; Genotype; Humans; Mumps; Mumps virus; Phylogeny; Whole Genome Sequencing
PubMed: 34757832
DOI: 10.1128/JCM.00841-21 -
The Journal of the American Osteopathic... Dec 2017The diagnosis and management of parotitis can be challenging. Patients often present with pain and edema in the neck, jaw, head, and ear due to congestion of the gland....
The diagnosis and management of parotitis can be challenging. Patients often present with pain and edema in the neck, jaw, head, and ear due to congestion of the gland. Parotitis is typically caused by an infection within the parotid gland and surrounding lymph nodes, and the infection can spread to nearby cervical fascial planes and cause major complications if not managed successfully. Specific guidelines for the outpatient management of parotitis are limited, and outpatient treatment failures are common, requiring inpatient therapy with multiple broad-spectrum antibiotics. In the current case, a comprehensive patient-centered approach was used to treat a woman whose overlapping clinical conditions, lifestyle, and work factors led to an infection of the parotid gland.
Topics: Anti-Bacterial Agents; Female; Humans; Levofloxacin; Manipulation, Osteopathic; Middle Aged; Parotitis; Tomography, X-Ray Computed; Xerostomia
PubMed: 29181524
DOI: 10.7556/jaoa.2017.152 -
Human Vaccines & Immunotherapeutics Jan 2021Mumps is a vaccine-preventable disease. Because the mumps vaccine can cause aseptic meningitis in rare cases, this vaccine is not routine in Japan. This has led to low... (Review)
Review
Mumps is a vaccine-preventable disease. Because the mumps vaccine can cause aseptic meningitis in rare cases, this vaccine is not routine in Japan. This has led to low vaccine coverage and severe disease burden in Japan. The present review summarizes mumps epidemiology and vaccination and discusses effective future strategies to mitigate the current disease burden of mumps in Japan. Although a recent study reported that mumps vaccine coverage rates are improving in Japan, current coverage rates are far below the optimal rate to suppress the ongoing epidemic, which has caused an average annual financial loss of 85 billion JPY between 2000 and 2016. Recent reports have demonstrated a much lower incidence of vaccine-induced aseptic meningitis in newly developed vaccines, especially when administered at 1 year of age. Cost-effectiveness studies suggest that routinization of the currently distributed domestic vaccine would be highly cost-effective. In addition, questionnaire surveillance data suggest that the majority of the Japanese population accepts the nominal risk of the vaccine when the proper information is provided. Finally, there are some successful programs in Japan that have attained high vaccine coverage rates with financial support from local governments. Taken together, these data suggest that the mumps vaccine should be immediately included in routine vaccines in Japan.
Topics: Humans; Infant; Japan; Measles-Mumps-Rubella Vaccine; Meningitis, Aseptic; Mumps; Mumps Vaccine; Vaccination
PubMed: 32530735
DOI: 10.1080/21645515.2020.1765619 -
Archives of Disease in Childhood Apr 1993
Topics: Child; Humans; Immunoglobulin A, Secretory; Parotitis; Recurrence
PubMed: 8503688
DOI: 10.1136/adc.68.4.526-c -
Canadian Medical Association Journal Mar 1967
Topics: Adolescent; Child; Child, Preschool; Female; Humans; Infant; Male; Mumps
PubMed: 6019680
DOI: No ID Found -
Anesthesiology 1962
Topics: Humans; Parotitis; Postoperative Period; Surgical Procedures, Operative
PubMed: 14466699
DOI: 10.1097/00000542-196209000-00011 -
Canadian Medical Association Journal Jul 1953
Topics: Encephalitis, Viral; Humans; Meningitis, Viral; Meningoencephalitis; Mumps
PubMed: 13059733
DOI: No ID Found