Neoplastic Process
Sezary syndrome
[ say-zah-ree sin-drome ]
Subclass of:
Lymphoproliferative Disorders;
Lymphoma, T-Cell, Cutaneous
Definitions related to sezary syndrome:
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A form of cutaneous T-cell lymphoma manifested by generalized exfoliative ERYTHRODERMA; PRURITUS; peripheral lymphadenopathy, and abnormal hyperchromatic mononuclear (cerebriform) cells in the skin, LYMPH NODES, and peripheral blood (Sezary cells).NLM Medical Subject HeadingsU.S. National Library of Medicine, 2021
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A form of cutaneous T-cell lymphoma, a cancerous disease that affects the skin.NCI Dictionary of Cancer TermsU.S. National Cancer Institute, 2021
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A generalized peripheral (mature) T-cell neoplasm characterized by the presence of erythroderma, lymphadenopathy, and neoplastic, cerebriform T-lymphocytes in the blood. Sezary syndrome is an aggressive disease. (WHO, 2001)NCI ThesaurusU.S. National Cancer Institute, 2021
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S�zary syndrome is an aggressive form of a type of blood cancer called cutaneous T-cell lymphoma. Cutaneous T-cell lymphomas occur when certain white blood cells, called T cells, become cancerous; these cancers characteristically affect the skin, causing different types of skin lesions. In S�zary syndrome, the cancerous T cells, called S�zary cells, are present in the blood, skin, and lymph nodes. A characteristic of S�zary cells is an abnormally shaped nucleus, described as cerebriform. People with S�zary syndrome develop a red, severely itchy rash (erythroderma) that covers large portions of their body. S�zary cells are found in the rash. However, the skin cells themselves are not cancerous; the skin problems result when S�zary cells move from the blood into the skin. People with S�zary syndrome also have enlarged lymph nodes (lymphadenopathy). Other common signs and symptoms of this condition include hair loss (alopecia), skin swelling (edema), thickened skin on the palms of the hands and soles of the feet (palmoplantar keratoderma), abnormalities of the fingernails and toenails, and lower eyelids that turn outward (ectropion). Some people with S�zary syndrome are less able to control their body temperature than people without the condition. The cancerous T cells can spread to other organs in the body, including the lymph nodes, liver, spleen, and bone marrow. In addition, affected individuals have an increased risk of developing another lymphoma or other type...MedlinePlus GeneticsU.S. National Library of Medicine, 2021
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Sezary syndrome is an aggressive form of cutaneous T-cell lymphoma which is a group of disorders that occur when T-cells (a type of white blood cell) become cancerous and affect the skin. It is characterized by a widespread red rash that may cover most of the body, the presence of cancerous T cells (called Sezary cells) in the blood, and...National Center for Advancing Translational Sciences
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