Immunologic Factor
certolizumab pegol
Brand Names:
Cimzia
Effect:
Immunologic Activity Alteration
May Treat:
Arthritis, Psoriatic;
Arthritis, Rheumatoid;
Crohn Disease;
Spondylitis, Ankylosing
More Information:
Definitions related to certolizumab pegol:
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A Fab fragment of a recombinant, humanized monoclonal antibody directed against the proinflammatory cytokine tumor necrosis factor-alpha (TNF-alpha) and conjugated to polyethylene glycol (PEG), with anti-inflammatory activity. Upon administration, certolizumab binds to TNF-alpha and prevents the interaction of this cytokine with endogenous cell surface receptors, thereby rendering TNF-alpha inactive and inhibiting TNF-mediated inflammatory responses. TNF-alpha is a protein involved in inflammation, cell survival, and apoptosis. Pegylation of certolizumab allows for an improved pharmacokinetic profile.NCI ThesaurusU.S. National Cancer Institute, 2021
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A polyethylene-glycolated Fab' fragment of TUMOR NECROSIS FACTOR antibody that binds specifically to TNF-ALPHA and neutralises it in a dose-dependent manner. It also inhibits the production of lipopolysaccharide-induced TNF-ALPHA and IL-1 BETA and is used to treat RHEUMATOID ARTHRITIS and PSORIATIC ARTHRITIS.NLM Medical Subject HeadingsU.S. National Library of Medicine, 2021
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