Cell or Molecular Dysfunction
chromothripsis
Subclass of:
Chromosome Aberrations
Definitions related to chromothripsis:
  • A cytogenetic abnormality characterized by the occurrence of a large number of chromosomal rearrangements that are restricted to sites in one or a few chromosomes. Chromothripsis may result from a single catastrophic event that causes multiple double-strand breaks, which are subsequently repaired or reassembled by error-prone DNA repair pathways or through aberrant DNA replication mechanisms.
    NCI
    U.S. National Cancer Institute, 2021
  • Massive number of chromosomal rearrangements and shattering that occurs in cancer cells. The breakpoints are located within one chromosome or chromosome arm.
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2025
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