Pharmacologic Substance
fluoxetine
flu·ox·e·tine [ floo-ok-seh-teen ]
Brand Names:
Prozac; RECONCILE; Sarafem; Symbyax
Effect:
Increased Central Nervous System Serotonin Activity
May Treat:
Bulimia;
Depressive Disorder, Major;
Obsessive-Compulsive Disorder;
Panic Disorder
More Information:
Definitions related to fluoxetine:
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A diphenhydramine derivative and selective serotonin reuptake inhibitor with antidepressant, anti-anxiety, antiobsessional and antibulimic activity and with potential immunomodulating activity. Upon administration, fluoxetine binds to the presynaptic serotonin (5-HT) receptor resulting in negative allosteric modulation of the receptor complex, thereby blocking recycling of serotonin by the presynaptic receptor. Inhibition of serotonin reuptake by fluoxetine enhances serotonergic function through serotonin accumulation in the synaptic space, resulting in long-term desensitization and downregulation of 5-HT receptors, preventing 5-HT-mediated signaling and leading to antidepressant, anti-anxiety, antiobsessional and antibulimic effects. In addition, fluoxetine may inhibit the expression of pro-inflammatory cytokines, including interleukin-6 (IL-6). This may prevent IL-6-mediated inflammation and cytokine storm.NCI ThesaurusU.S. National Cancer Institute, 2021
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A drug used to treat depression. It belongs to the family of drugs called antidepressants.NCI Dictionary of Cancer TermsU.S. National Cancer Institute, 2021
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N-methyl-gamma-(4-(trifluoromethyl) -phenoxy)-benzenepropanamine; used in the treatment of depression; action thought to be linked to its inhibition of CNS neuronal uptake of serotonin.CRISP ThesaurusNational Institutes of Health, 2006
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The first highly specific serotonin uptake inhibitor. It is used as an antidepressant and often has a more acceptable side-effects profile than traditional antidepressants.NLM Medical Subject HeadingsU.S. National Library of Medicine, 2021
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Prozac, trade name of fluoxetine hydrochloride, first of the class of antidepressant medications called selective serotonin reuptake inhibitors (SSRIs). It was introduced by Eli Lilly pharmaceutical company as a treatment for clinical depression in 1986. Prozac is also used to treat a variety of...Encyclopedia Britannica, Inc., 2020
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