A diphenhydramine derivative and selective serotonin reuptake inhibitor with antidepressant, anti-anxiety, antiobsessional and antibulimic activity and with potential immunomodulating activity. Upon administration, fluoxetine binds to the presynaptic serotonin (5-HT) receptor resulting in negative allosteric modulation of the receptor complex, thereby blocking recycling of serotonin by the presynaptic receptor. Inhibition of serotonin reuptake by fluoxetine enhances serotonergic function through serotonin accumulation in the synaptic space, resulting in long-term desensitization and downregulation of 5-HT receptors, preventing 5-HT-mediated signaling and leading to antidepressant, anti-anxiety, antiobsessional and antibulimic effects. In addition, fluoxetine may inhibit the expression of pro-inflammatory cytokines, including interleukin-6 (IL-6). This may prevent IL-6-mediated inflammation and cytokine storm.

A drug used to treat depression. It belongs to the family of drugs called antidepressants.

N-methyl-gamma-(4-(trifluoromethyl) -phenoxy)-benzenepropanamine; used in the treatment of depression; action thought to be linked to its inhibition of CNS neuronal uptake of serotonin.

The first highly specific serotonin uptake inhibitor. It is used as an antidepressant and often has a more acceptable side-effects profile than traditional antidepressants.

Prozac, trade name of fluoxetine hydrochloride, first of the class of antidepressant medications called selective serotonin reuptake inhibitors (SSRIs). It was introduced by Eli Lilly pharmaceutical company as a treatment for clinical depression in 1986. Prozac is also used to treat a variety of...