Pharmacologic Substance
promethazine Audio
pro·meth·a·zine [ proh-meth-uh-zeen, -zin ]
Brand Names:
Phenadoz; Phenergan; Promethegan
Effect:
Decreased Dopamine Activity; Decreased Histamine Activity; Decreased Norepinephrine Activity; Emesis Suppression
May Treat:
Anaphylaxis; Conjunctivitis, Allergic; Motion Sickness; Nausea; Pain; Postoperative Complications; Rhinitis, Allergic, Perennial; Urticaria; Vomiting
More Information:
ChemID; DrugBank; DailyMed; PDR
Definitions related to promethazine:
  • A phenothiazine derivative with antiemetic and antihistaminic properties. Promethazine antagonizes the central and peripheral effects of histamine mediated by histamine H1 receptors. The effects include bronchoconstriction, vasodilation and spasmodic contractions of gastrointestinal smooth muscle. In addition, this agent binds to muscarinic receptors, resulting in anticholinergic and antiemetic activities.
    NCI
    U.S. National Cancer Institute, 2021
  • A phenothiazine derivative with histamine H1-blocking, antimuscarinic, and sedative properties. It is used as an antiallergic, in pruritus, for motion sickness and sedation, and also in animals.
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2025
  • Promethazine, synthetic drug used to counteract the histamine reaction, as in allergies. Promethazine, introduced into medicine in the 1940s, is used in the form of its hydrochloride. It is administered orally in tablets and syrups and intramuscularly in an aqueous solution. Promethazine is...
    Encyclopedia Britannica
    Encyclopedia Britannica, Inc., 2025
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