Pharmacologic Substance
dacarbazine Audio
[ duh-kahr-buh-zeen ]
Effect:
Decreased DNA Integrity; Decreased Protein Synthesis; Decreased RNA Integrity
May Treat:
Carcinoma, Islet Cell; Carcinoma, Medullary; Fibrosarcoma; Hodgkin Disease; Melanoma; Neuroblastoma; Rhabdomyosarcoma
More Information:
ChemID; DrugBank; DailyMed; PDR
Definitions related to dacarbazine:
  • A drug that is used to treat Hodgkin lymphoma and malignant melanoma and is being studied in the treatment of other types of cancer. It attaches to DNA in cells and may kill cancer cells. It is a type of alkylating agent.
    NCI Dictionary of Cancer Terms
    U.S. National Cancer Institute, 2021
  • A triazene derivative with antineoplastic activity. Dacarbazine alkylates and cross-links DNA during all phases of the cell cycle, resulting in disruption of DNA function, cell cycle arrest, and apoptosis. (NCI04)
    NCI
    U.S. National Cancer Institute, 2021
  • An antineoplastic agent. It has significant activity against melanomas. (from Martindale, The Extra Pharmacopoeia, 31st ed, p564)
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2025
  • Cytotoxic alkylating agent used as an antineoplastic primarily for treatment of malignant melanoma and in combination chemotherapy for Hodgkin's disease and sarcomas; administered intravenously; abbreviated DTIC.
    CRISP Thesaurus
    National Institutes of Health, 2006
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This content should not be used in place of medically-reviewed decision support reference material or professional medical advice. Some terms may have alternate or updated definitions not reflected in this set. The definitions on this page should not be considered complete or up to date.