Pharmacologic Substance
clotrimazole
Brand Names:
Aardora Anti-Fungal Maximum Strength; Alevazol; Clotrimazoil; Cruex Antifungal; Dermatin; Fungicure Solution; Fungistat; Jock-Eze; Lotrimin; Lotrisone; LoZatom; Malotic; Mometamax; Motazol; Mycelex Troches; Otomax; Pattotic; Tri-Otic for Canines; Vetromax
Effect:
Decreased Cell Wall Integrity
May Prevent:
Candidiasis, Oral
May Treat:
Candidiasis, Cutaneous; Candidiasis, Oral; Candidiasis, Vulvovaginal; Tinea Pedis
More Information:
ChemID; DrugBank; DailyMed; DrugInfo; PDR
Definitions related to clotrimazole:
  • A synthetic, imidazole derivate with broad-spectrum, antifungal activity. Clotrimazole inhibits biosynthesis of sterols, particularly ergosterol, an essential component of the fungal cell membrane, thereby damaging and affecting the permeability of the cell membrane. This results in leakage and loss of essential intracellular compounds, and eventually causes cell lysis.
    NCI Thesaurus
    U.S. National Cancer Institute, 2021
  • An imidazole derivative with a broad spectrum of antimycotic activity. It inhibits biosynthesis of the sterol ergostol, an important component of fungal CELL MEMBRANES. Its action leads to increased membrane permeability and apparent disruption of enzyme systems bound to the membrane.
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2021
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