Pharmacologic Substance
methotrimeprazine
Effect:
Decreased Acetylcholine Activity; Decreased Brain Stem Dopamine Activity; Decreased Brain Stem Organized Electrical Activity; Decreased Histamine Activity; Hypothalamic Endocrine Activity Alteration
May Treat:
Anxiety Disorders; Bipolar Disorder; Pain; Psychotic Disorders; Schizophrenia
Definitions related to methotrimeprazine:
  • (levomepromazine) A phenothiazine and typical antipsychotic agent, with sedative/hypnotic, anxiolytic, antiemetic, analgesic and antipsychotic activities. Although the exact mechanism of action of levomepromazine is not fully known, upon administration, this agent appears to act as an antagonist for a variety of receptors in the central nervous system (CNS), including adrenergic, dopamine, histamine, cholinergic and serotonin (5-hydroxytryptamine; 5-HT) receptors. Blocking these receptors results in levomepromazine's pharmacologic effects.
    NCI Thesaurus
    U.S. National Cancer Institute, 2021
  • A phenothiazine with pharmacological activity similar to that of both CHLORPROMAZINE and PROMETHAZINE. It has the histamine-antagonist properties of the antihistamines together with CENTRAL NERVOUS SYSTEM effects resembling those of chlorpromazine. (From Martindale, The Extra Pharmacopoeia, 30th ed, p604)
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2021
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This content should not be used in place of medically-reviewed decision support reference material or professional medical advice. Some terms may have alternate or updated definitions not reflected in this set. The definitions on this page should not be considered complete or up to date.