Pharmacologic Substance
perphenazine
[ per-fen-uh-zeen, -zin ]
Effect:
Decreased Dopamine Activity; Decreased Norepinephrine Activity; Hypothalamic Endocrine Activity Alteration
May Treat:
Huntington Disease; Nausea; Psychotic Disorders; Reye Syndrome; Schizophrenia; Substance Withdrawal Syndrome; Torticollis; Tourette Syndrome; Vomiting
More Information:
ChemID; DrugBank; DailyMed; DrugInfo; PDR
Definitions related to perphenazine:
  • A phenothiazine derivative and a dopamine antagonist with antiemetic and antipsychotic properties. Perphenazine blocks postsynaptic dopamine 2(D2) receptors in the mesolimbic and medullary chemoreceptor trigger zone (CTZ), thereby preventing the excess of dopamine in the brain. This leads to reduction in psychotic symptoms, such as hallucinations and delusions. Perphenazine appears to exert its antiemetic activity by blocking the dopamine and histamine-1 receptor in the CTZ thereby relieving nausea and vomiting in the brain. In addition, perphenazine binds to alpha-adrenergic receptors.
    NCI Thesaurus
    U.S. National Cancer Institute, 2021
  • An antipsychotic phenothiazine derivative with actions and uses similar to those of CHLORPROMAZINE.
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2021
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