Pharmacologic Substance
chlorpromazine Audio
chlor·prom·a·zine [ klawr-prom-uh-zeen, klohr- ]
Effect:
Decreased Dopamine Activity; Decreased Histamine Activity; Decreased Norepinephrine Activity; Decreased Serotonin Activity; Hypothalamic Endocrine Activity Alteration
May Treat:
Anxiety Disorders; Attention Deficit and Disruptive Behavior Disorders; Child Behavior Disorders; Hiccup; Nausea; Porphyria, Acute Intermittent; Psychotic Disorders; Schizophrenia; Tetanus; Vomiting
More Information:
ChemID; DrugBank; DailyMed; DrugInfo; PDR
Definitions related to chlorpromazine:
  • A phenothiazine and traditional antipsychotic agent with anti-emetic activity. Chlorpromazine exerts its antipsychotic effect by blocking postsynaptic dopamine receptors in cortical and limbic areas of the brain, thereby preventing the excess of dopamine in the brain. This leads to a reduction in psychotic symptoms, such as hallucinations and delusions. Chlorpromazine appears to exert its anti-emetic activity by blocking the dopamine receptors in the chemical trigger zone (CTZ) in the brain, thereby relieving nausea and vomiting.
    NCI Thesaurus
    U.S. National Cancer Institute, 2021
  • Prototypical phenothiazine antipsychotic drug; antipsychotic actions are thought to be due to long-term adaptation by the brain to blocking dopamine receptors; chlorpromazine has several other actions and therapeutic uses, including as an antiemetic and in the treatment of intractable hiccup.
    CRISP Thesaurus
    National Institutes of Health, 2006
  • The prototypical phenothiazine antipsychotic drug. Like the other drugs in this class chlorpromazine's antipsychotic actions are thought to be due to long-term adaptation by the brain to blocking DOPAMINE RECEPTORS. Chlorpromazine has several other actions and therapeutic uses, including as an antiemetic and in the treatment of intractable hiccup.
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2021
  • Chlorpromazine, potent synthetic tranquilizing drug that acts selectively upon the higher centres in the brain as a depressant of the central nervous system. It is used in the treatment of persons with psychotic disorders. Chlorpromazine was first synthesized in 1950 and became generally available...
    Encyclopedia Britannica
    Encyclopedia Britannica, Inc., 2020
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