Pharmacologic Substance
prochlorperazine Audio
pro·chlor·per·a·zine [ proh-klor-payr-uh-zeen ]
Brand Names:
Compazine; Compro
Effect:
Decreased Brain Stem Dopamine Activity; Decreased Central Nervous System Acetylcholine Activity; Decreased Central Nervous System Norepinephrine Activity; Emesis Suppression
May Prevent:
Nausea; Vomiting
May Treat:
Anxiety Disorders; Dementia; Nausea; Psychotic Disorders; Schizophrenia; Vomiting
More Information:
ChemID; DrugBank; DailyMed; DrugInfo; PDR
Definitions related to prochlorperazine:
  • A drug used to prevent or reduce nausea and vomiting. It belongs to the family of drugs called antiemetics.
    NCI Dictionary of Cancer Terms
    U.S. National Cancer Institute, 2021
  • A phenothiazine antipsychotic used principally in the treatment of NAUSEA; VOMITING; and VERTIGO. It is more likely than CHLORPROMAZINE to cause EXTRAPYRAMIDAL DISORDERS. (From Martindale, The Extra Pharmacopoeia, 30th ed, p612)
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2021
  • A synthetic propylpiperazine derivative of phenothiazine with antiemetic, antipsychotic, antihistaminic, and anticholinergic activities. Prochlorperazine antagonizes the dopamine D2-receptor in the chemoreceptor trigger zone (CTZ) of the brain and may prevent chemotherapy-induced emesis. (NCI04)
    NCI Thesaurus
    U.S. National Cancer Institute, 2021
  • Phenothiazine derivative used chiefly as an antiemetic.
    CRISP Thesaurus
    National Institutes of Health, 2006
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This content should not be used in place of medically-reviewed decision support reference material or professional medical advice. Some terms may have alternate or updated definitions not reflected in this set. The definitions on this page should not be considered complete or up to date.