Pharmacologic Substance
triamcinolone Audio
[ trahy-am-sin-uh-lohn ]
Brand Names:
Aller-Cort; Aristospan; Dermalone; Dermasorb TA; Genesis; Hexatrione; Kenalog; Nasacort; Oralone; Trianex; Triderm; Triesence; Tritocin; Vetalog; Zilretta
Effect:
Carbohydrate Metabolism Alteration; Decreased Capillary Permeability; Decreased Cytokine Activity; Decreased Fibroblast Migration; Decreased Glucocorticoid Secretion; Decreased Leukotriene Activity; Decreased Polymorphonuclear Leukocyte Migration; Decreased Prostaglandin Activity; Decreased Protein Synthesis; Decreased Thromboxane Activity; Lipid Metabolism Alteration; Lysosomal Function Alteration
May Prevent:
Arthritis, Gouty; Arthritis, Rheumatoid; Asthma
May Treat:
Adrenal Insufficiency; Anemia, Hemolytic; Berylliosis; Bronchial Spasm; Colitis, Ulcerative; Dermatitis Herpetiformis; Dermatitis, Atopic; Erythema Multiforme; Facial Dermatoses; Foot Dermatoses; Hand Dermatoses; Hypercalcemia; Inflammation; Leg Dermatoses; Lupus Erythematosus, Systemic; Multiple Sclerosis; Nephrotic Syndrome; Pemphigus; Rheumatic Diseases; Rhinitis, Allergic, Perennial; Scalp Dermatoses; Serum Sickness; Spondylitis, Ankylosing; Synovitis; Thyroiditis; Tuberculosis, Pulmonary; Uveitis
More Information:
ChemID; DrugBank; DailyMed; DrugInfo; PDR
Definitions related to triamcinolone:
  • A glucocorticoid given, as the free alcohol or in esterified form, orally, intramuscularly, by local injection, by inhalation, or applied topically in the management of various disorders in which corticosteroids are indicated. (From Martindale, The Extra Pharmacopoeia, 30th ed, p739)
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2021
  • A substance that is being studied for the prevention of nonmelanoma skin cancer. It is an anti-inflammatory drug that is applied to the skin to relieve irritation, rashes, and infections. It belongs to the family of drugs called topical corticosteroids.
    NCI Dictionary of Cancer Terms
    U.S. National Cancer Institute, 2021
  • A synthetic glucocorticoid with anti-inflammatory and immunomodulating properties. Upon cell entry, triamcinolone binds to and activates the glucocorticoid receptor, which leads to translocation of the ligand-receptor complex to the nucleus and induces expression of glucocorticoid-responsive genes such as lipocortins. Lipocortins inhibit phospholipase A2, thereby blocking the release of arachidonic acid from membrane phospholipids and preventing the synthesis of prostaglandins and leukotrienes, both mediators of inflammation. In addition, pro-inflammatory cytokine production, including interleukin (IL)-1and IL-6, and the activation of cytotoxic T-lymphocytes is also inhibited. T-cells are prevented from making IL-2 and proliferating. This agent also decreases the number of circulating lymphocytes, induces cell differentiation, and stimulates apoptosis through increasing Ikappa-B expression and curtailing activation of nuclear factor (NF)kappa-B.
    NCI Thesaurus
    U.S. National Cancer Institute, 2021
  • Synthetic glucocorticoid used in replacement therapy for adrenal insufficiency and as an anti-inflammatory and immunosuppressant in a variety of disorders.
    CRISP Thesaurus
    National Institutes of Health, 2006
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This content should not be used in place of medically-reviewed decision support reference material or professional medical advice. Some terms may have alternate or updated definitions not reflected in this set. The definitions on this page should not be considered complete or up to date.