Pharmacologic Substance
trifluoperazine Audio
tri·flu·o·per·a·zine [ trahy-floo-uh-per-uh-zeen ]
Effect:
Decreased Dopamine Activity; Decreased Norepinephrine Activity; Hypothalamic Endocrine Activity Alteration
May Treat:
Anxiety Disorders; Psychotic Disorders; Schizophrenia
More Information:
ChemID; DrugBank; DailyMed; PDR
Definitions related to trifluoperazine:
  • A phenothiazine derivative and a dopamine antagonist with antipsychotic and antiemetic activities. Trifluoperazine exerts its antipsychotic effect by blocking central dopamine receptors, thereby preventing effects such as delusions and hallucinations caused by an excess of dopamine. This agent also functions as a calmodulin inhibitor, thereby leading to elevation of cytosolic calcium.
    NCI
    U.S. National Cancer Institute, 2021
  • A phenothiazine with actions similar to CHLORPROMAZINE. It is used as an antipsychotic and an antiemetic.
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2025
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