Biologically Active Substance
vinblastine Audio
vin·blas·tine [ vin-blas-teen ]
Effect:
Cellular Growth Phase Arrest; Decreased Mitosis; Increased Cellular Death
May Treat:
Breast Neoplasms; Choriocarcinoma; Head and Neck Neoplasms; Histiocytosis; Hodgkin Disease; Kidney Neoplasms; Lung Neoplasms; Mycosis Fungoides; Purpura, Thrombocytopenic, Idiopathic; Sarcoma, Kaposi; Testicular Neoplasms
More Information:
ChemID; DrugBank; DailyMed; DrugInfo; PDR
Definitions related to vinblastine:
  • A natural alkaloid isolated from the plant Vinca rosea Linn. Vinblastine binds to tubulin and inhibits microtubule formation, resulting in disruption of mitotic spindle assembly and arrest of tumor cells in the M phase of the cell cycle. This agent may also interfere with amino acid, cyclic AMP, and glutathione metabolism; calmodulin-dependent Ca++ -transport ATPase activity; cellular respiration; and nucleic acid and lipid biosynthesis. (NCI04)
    NCI Thesaurus
    U.S. National Cancer Institute, 2021
  • Antitumor alkaloid isolated from Vinca rosea. (Merck, 11th ed.)
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2021
  • Promotes paracrystalline aggregates of tubulin and thus inhibits microtubule formation; used as a cytologic probe for microtubule function, and clinically as an antineoplastic.
    CRISP Thesaurus
    National Institutes of Health, 2006
  • The active ingredient in a drug used together with other drugs to treat several types of cancer, including advanced Hodgkin lymphoma and advanced testicular germinal-cell cancers. It is also being studied in the treatment of other types of cancer. Vinblastine comes from the periwinkle plant Vinca rosea Linn. It blocks cell growth by stopping cell division and may kill cancer cells. It is a type of vinca alkaloid and a type of antimitotic agent.
    NCI Dictionary of Cancer Terms
    U.S. National Cancer Institute, 2021
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This content should not be used in place of medically-reviewed decision support reference material or professional medical advice. Some terms may have alternate or updated definitions not reflected in this set. The definitions on this page should not be considered complete or up to date.