Pharmacologic Substance
vincristine Audio
vin·cris·tine [ vin-kris-teen ]
Brand Names:
Marqibo; Vincasar
Effect:
Cellular Growth Phase Arrest; Decreased Mitosis; Increased Cellular Death
May Treat:
Hodgkin Disease; Leukemia; Lymphoma, Non-Hodgkin; Neuroblastoma; Rhabdomyosarcoma; Wilms Tumor
More Information:
ChemID; DrugBank; DailyMed; DrugInfo; PDR
Definitions related to vincristine:
  • A natural alkaloid isolated from the plant Vinca rosea Linn. Vincristine binds irreversibly to microtubules and spindle proteins in S phase of the cell cycle and interferes with the formation of the mitotic spindle, thereby arresting tumor cells in metaphase. This agent also depolymerizes microtubules and may also interfere with amino acid, cyclic AMP, and glutathione metabolism; calmodulin-dependent Ca++ -transport ATPase activity; cellular respiration; and nucleic acid and lipid biosynthesis. (NCI04)
    NCI Thesaurus
    U.S. National Cancer Institute, 2021
  • An antitumor alkaloid isolated from VINCA ROSEA. (Merck, 11th ed.)
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2021
  • Inhibits microtubule formation in the mitotic spindle, resulting in an arrest of dividing cells at the metaphase stage.
    CRISP Thesaurus
    National Institutes of Health, 2006
  • The active ingredient in a drug used to treat acute leukemia. It is used in combination with other drugs to treat Hodgkin disease, non-Hodgkin lymphoma, rhabdomyosarcoma, neuroblastoma, and Wilms tumor. Vincristine is also being studied in the treatment of other types of cancer. It blocks cell growth by stopping cell division. It is a type of vinca alkaloid and a type of antimitotic agent.
    NCI Dictionary of Cancer Terms
    U.S. National Cancer Institute, 2021
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This content should not be used in place of medically-reviewed decision support reference material or professional medical advice. Some terms may have alternate or updated definitions not reflected in this set. The definitions on this page should not be considered complete or up to date.