Pharmacologic Substance
acitretin Audio
[ a-sih-treh-tin ]
Brand Names:
Soriatane
Effect:
Decreased Epithelial Proliferation; Decreased Immunologically Active Molecule Activity; Keratin Alteration
May Treat:
Psoriasis
More Information:
ChemID; DrugBank; DailyMed; DrugInfo; PDR
Definitions related to acitretin:
  • A substance that is used in the prevention of cancer and in the treatment of psoriasis. It belongs to the family of drugs called retinoids.
    NCI Dictionary of Cancer Terms
    U.S. National Cancer Institute, 2021
  • An oral retinoid effective in the treatment of psoriasis. It is the major metabolite of ETRETINATE with the advantage of a much shorter half-life when compared with etretinate.
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2021
  • An orally-active metabolite of the synthetic aromatic retinoic acid agent etretinate with potential antineoplastic, chemopreventive, anti-psoratic, and embryotoxic properties. Acitretin activates nuclear retinoic acid receptors (RAR), resulting in induction of cell differentiation, inhibition of cell proliferation, and inhibition of tissue infiltration by inflammatory cells. This agent may also inhibit tumor angiogenesis. (NCI04)
    NCI Thesaurus
    U.S. National Cancer Institute, 2021
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