Pharmacologic Substance
aripiprazole
Brand Names:
Abilify
Effect:
Decreased Dopamine Activity; Decreased Serotonin Activity
May Treat:
Schizophrenia
More Information:
ChemID; DrugBank; DailyMed; PDR
Definitions related to aripiprazole:
  • A piperazine and quinolone derivative that is used primarily as an antipsychotic agent. It is a partial agonist of SEROTONIN RECEPTOR, 5-HT1A and DOPAMINE D2 RECEPTORS, where it also functions as a post-synaptic antagonist, and an antagonist of SEROTONIN RECEPTOR, 5-HT2A. It is used for the treatment of SCHIZOPHRENIA and BIPOLAR DISORDER, and as an adjunct therapy for the treatment of depression.
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2025
  • A quinoline derivate and atypical anti-psychotic agent. Aripiprazole has partial agonistic activity at dopamine D2 receptors and serotonin 5-HT1A receptors, as well as potent antagonistic activity on serotonin 5-HT2A receptors. This drug stabilizes dopamine and serotonin activity in the limbic and cortical system. Aripiprazole is used in managing symptoms of schizophrenia and of acute manic and mixed episodes associated with bipolar I disorders.
    NCI
    U.S. National Cancer Institute, 2021
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