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Biochemistry and Molecular Biology... Jul 2017To date, national interests, policies, and calls for transformation of undergraduate education have been the main drivers of research integration into the undergraduate...
To date, national interests, policies, and calls for transformation of undergraduate education have been the main drivers of research integration into the undergraduate curriculum, briefly described here. The New Horizons in Biochemistry and Molecular Biology Education conference at the Weizmann Institute of Science (Israel) this fall presents an exciting opportunity to discuss integration of undergraduate research into the curriculum and other cutting-edge topics in biochemistry and molecular biology education from a cross-national perspective. I look forward to exploring prospects for international collaboration on research and development of course-based undergraduate research experiences and on STEM education in general. © 2017 by The International Union of Biochemistry and Molecular Biology, 45(4):293-298, 2017.
Topics: Biochemistry; Curriculum; Education, Medical, Undergraduate; Educational Measurement; Humans; Molecular Biology; Science; Students; Universities
PubMed: 28696054
DOI: 10.1002/bmb.21070 -
Biochemistry and Molecular Biology... Jan 2017Integration of research experience into classroom is an important and vital experience for all undergraduates. These course-based undergraduate research experiences...
Integration of research experience into classroom is an important and vital experience for all undergraduates. These course-based undergraduate research experiences (CUREs) have grown from independent instructor lead projects to large consortium driven experiences. The impact and importance of CUREs on students at all levels in biochemistry was the focus of a National Science Foundation funded think tank. The state of biochemistry CUREs and suggestions for moving biochemistry forward as well as a practical guide (supplementary material) are reported here. © 2016 by The International Union of Biochemistry and Molecular Biology, 45(1):7-12, 2017.
Topics: Biochemistry; Biomedical Research; Curriculum; Humans; Students; Universities
PubMed: 27357379
DOI: 10.1002/bmb.20989 -
FEBS Letters Jun 2015
Topics: Berlin; Biochemistry; Molecular Biology
PubMed: 25975518
DOI: 10.1016/j.febslet.2015.05.011 -
Essays in Biochemistry Oct 2017Within every living organism, countless reactions occur every second. These reactions typically occur more rapidly and with greater efficiency than would be possible... (Review)
Review
Within every living organism, countless reactions occur every second. These reactions typically occur more rapidly and with greater efficiency than would be possible under the same conditions in the chemical laboratory, and while using only the subset of elements that are readily available in nature. Despite these apparent differences between life and the laboratory, biological reactions are governed by the same rules as any other chemical reaction. Thus, a firm understanding of the fundamentals of chemistry is invaluable in biochemistry. There are entire textbooks devoted to the application of chemical principles in biological systems and so it is not possible to cover all of the relevant topics in depth in this short article. The aim is instead to provide a brief overview of those areas in chemistry that are most relevant to biochemistry. We summarize the basic principles, give examples of how these principles are applied in biological systems and suggest further reading on individual topics.
Topics: Animals; Biochemistry; Humans; Metabolome; Organic Chemicals; Organic Chemistry Phenomena
PubMed: 28951470
DOI: 10.1042/EBC20160094 -
Biochemistry and Molecular Biology... 2014
Topics: Biochemistry; Education; Molecular Biology; New York
PubMed: 24740931
DOI: 10.1002/bmb.20796 -
Journal of Molecular Biology Nov 2017Post-translational protein modification by ubiquitin (Ub) and Ub-like modifiers is orchestrated by the sequential action of Ub-activating, -conjugating, and -ligating... (Review)
Review
Post-translational protein modification by ubiquitin (Ub) and Ub-like modifiers is orchestrated by the sequential action of Ub-activating, -conjugating, and -ligating enzymes to regulate a vast array of fundamental biological processes. Unsurprisingly, the dysregulation of the intricate interplay between ubiquitination and deubiquitination gives rise to numerous pathologies, most notably cancer and neurodegenerative diseases. While activity-based probes (ABPs) and assay reagents have been extensively developed and applied for deubiquitinating enzymes, similar tools for the Ub cascade have only recently emerged. Given the recent efforts to develop inhibitors for the Ub system, the urgency for developing ABPs and assay reagents is imminent. In this light, we comprehensively discuss the currently available ABPs with a focus on the newly developed reagents targeting the Ub cascade while illustrating their potential applications.
Topics: Biochemistry; Eukaryotic Cells; Molecular Biology; Ubiquitination
PubMed: 28410891
DOI: 10.1016/j.jmb.2017.04.002 -
International Journal of Molecular... May 2023This Editorial highlights the various observations made in the Special Issue of the on "Recent Advances in Biochemistry and Molecular Biology of Infectious Diseases"...
This Editorial highlights the various observations made in the Special Issue of the on "Recent Advances in Biochemistry and Molecular Biology of Infectious Diseases" [...].
Topics: Humans; Molecular Biology; Biochemistry; Communicable Diseases
PubMed: 37240305
DOI: 10.3390/ijms24108958 -
Biomolecules Jul 2023Homocysteine is increasingly recognized as an important molecule in a wide variety of cellular functions [...].
Homocysteine is increasingly recognized as an important molecule in a wide variety of cellular functions [...].
Topics: Homocysteine; Molecular Biology; Biochemistry
PubMed: 37509148
DOI: 10.3390/biom13071111 -
Biochemistry Nov 2021The measurement of ion concentrations and fluxes inside living cells is key to understanding cellular physiology. Fluorescent indicators that can infiltrate and provide...
The measurement of ion concentrations and fluxes inside living cells is key to understanding cellular physiology. Fluorescent indicators that can infiltrate and provide intel on the cellular environment are critical tools for biological research. Developing these molecular informants began with the seminal work of Racker and colleagues ( (1979) 18, 2210), who demonstrated the passive loading of fluorescein in living cells to measure changes in intracellular pH. This work continues, employing a mix of old and new tradecraft to create innovative agents for monitoring ions inside living systems.
Topics: Biochemistry; Fluorescein; Fluorescent Dyes; History, 20th Century; Hydrogen-Ion Concentration; Intravital Microscopy; Microscopy, Fluorescence
PubMed: 34096721
DOI: 10.1021/acs.biochem.1c00299 -
Current Opinion in Neurobiology Apr 2017Neuroscience has come to mean the study of electrophysiology of neurons and synapses, micro and macro-scale neuroanatomy, and the functional organization of brain areas.... (Review)
Review
Neuroscience has come to mean the study of electrophysiology of neurons and synapses, micro and macro-scale neuroanatomy, and the functional organization of brain areas. The molecular axis of the field, as reflected in textbooks, often includes only descriptions of the structure and function of individual channels and receptor proteins, and the extracellular signals that guide development and repair. Studies of cytosolic 'molecular machines', large assemblies of proteins that orchestrate regulation of neuronal functions, have been neglected. However, a complete understanding of brain function that will enable new strategies for treatment of the most intractable neural disorders will require that in vitro biochemical studies of molecular machines be reintegrated into the field of neuroscience.
Topics: Biochemistry; Brain; Humans; Nervous System Diseases; Neurons; Neurosciences
PubMed: 28160757
DOI: 10.1016/j.conb.2017.01.004