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Current Biology : CB Dec 2015
Topics: Biochemistry; Cell Proliferation; History, 20th Century; History, 21st Century; India; Molecular Biology; Neoplasms; United States; Virginia
PubMed: 27027134
DOI: 10.1016/j.cub.2015.10.035 -
The Journal of Biological Chemistry Apr 2003
Topics: Biochemistry; Chemistry; History, 20th Century; United States
PubMed: 12556464
DOI: 10.1074/jbc.X300001200 -
Journal of Lipid Research Jul 2020
Topics: Biochemistry; Molecular Biology; Publications; Societies, Scientific
PubMed: 32398265
DOI: 10.1194/jlr.E120000903 -
Journal of Molecular Biology Nov 2017Post-translational protein modification by ubiquitin (Ub) and Ub-like modifiers is orchestrated by the sequential action of Ub-activating, -conjugating, and -ligating... (Review)
Review
Post-translational protein modification by ubiquitin (Ub) and Ub-like modifiers is orchestrated by the sequential action of Ub-activating, -conjugating, and -ligating enzymes to regulate a vast array of fundamental biological processes. Unsurprisingly, the dysregulation of the intricate interplay between ubiquitination and deubiquitination gives rise to numerous pathologies, most notably cancer and neurodegenerative diseases. While activity-based probes (ABPs) and assay reagents have been extensively developed and applied for deubiquitinating enzymes, similar tools for the Ub cascade have only recently emerged. Given the recent efforts to develop inhibitors for the Ub system, the urgency for developing ABPs and assay reagents is imminent. In this light, we comprehensively discuss the currently available ABPs with a focus on the newly developed reagents targeting the Ub cascade while illustrating their potential applications.
Topics: Biochemistry; Eukaryotic Cells; Molecular Biology; Ubiquitination
PubMed: 28410891
DOI: 10.1016/j.jmb.2017.04.002 -
The FEBS Journal Aug 2021In this special interview series, we profile members of The FEBS Journal editorial board to highlight their research focus, perspectives on the journal and future...
In this special interview series, we profile members of The FEBS Journal editorial board to highlight their research focus, perspectives on the journal and future directions in their field. Nikos Karamanos is Professor of Biochemistry in the Department of Chemistry, University of Patras in Greece. He joined the editorial board of The FEBS Journal in 2020, having previously served on the advisory board for several years.
Topics: Biochemistry; Greece; History, 20th Century; History, 21st Century
PubMed: 34342145
DOI: 10.1111/febs.15891 -
Acta Biochimica Polonica 2003
Topics: Biochemistry; History, 20th Century; Periodicals as Topic; Poland
PubMed: 14571894
DOI: No ID Found -
Current Opinion in Neurobiology Apr 2017Neuroscience has come to mean the study of electrophysiology of neurons and synapses, micro and macro-scale neuroanatomy, and the functional organization of brain areas.... (Review)
Review
Neuroscience has come to mean the study of electrophysiology of neurons and synapses, micro and macro-scale neuroanatomy, and the functional organization of brain areas. The molecular axis of the field, as reflected in textbooks, often includes only descriptions of the structure and function of individual channels and receptor proteins, and the extracellular signals that guide development and repair. Studies of cytosolic 'molecular machines', large assemblies of proteins that orchestrate regulation of neuronal functions, have been neglected. However, a complete understanding of brain function that will enable new strategies for treatment of the most intractable neural disorders will require that in vitro biochemical studies of molecular machines be reintegrated into the field of neuroscience.
Topics: Biochemistry; Brain; Humans; Nervous System Diseases; Neurons; Neurosciences
PubMed: 28160757
DOI: 10.1016/j.conb.2017.01.004 -
Biochemistry and Molecular Biology... Jul 2019
Topics: Biochemistry; Humans; Interdisciplinary Studies; Molecular Biology
PubMed: 31246359
DOI: 10.1002/bmb.21283 -
Biochemistry and Molecular Biology... 2014
Topics: Biochemistry; Carbon Dioxide; Ecosystem; Humans; Molecular Biology; Oxygen; Photosynthesis; Plants; Thinking
PubMed: 25052343
DOI: 10.1002/bmb.20814 -
Biochemistry and Molecular Biology... Jan 2020
Topics: Biochemistry; Humans; Molecular Biology; Publishing; Reproducibility of Results
PubMed: 31868993
DOI: 10.1002/bmb.21329