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Biomedicines Oct 2022Aging constitutes progressive physiological changes in an organism. These changes alter the normal biological functions, such as the ability to manage metabolic stress,... (Review)
Review
Aging constitutes progressive physiological changes in an organism. These changes alter the normal biological functions, such as the ability to manage metabolic stress, and eventually lead to cellular senescence. The process itself is characterized by nine hallmarks: genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis, deregulated nutrient sensing, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, and altered intercellular communication. These hallmarks are risk factors for pathologies, such as cardiovascular diseases, neurodegenerative diseases, and cancer. Emerging evidence has been focused on examining the genetic pathways and biological processes in organisms surrounding these nine hallmarks. From here, the therapeutic approaches can be addressed in hopes of slowing the progression of aging. In this review, data have been collected on the hallmarks and their relative contributions to aging and supplemented with in vitro and in vivo antiaging research experiments. It is the intention of this article to highlight the most important antiaging strategies that researchers have proposed, including preventive measures, systemic therapeutic agents, and invasive procedures, that will promote healthy aging and increase human life expectancy with decreased side effects.
PubMed: 36289777
DOI: 10.3390/biomedicines10102515 -
Biomedicines Feb 2020Herbal extracts and isolated plant compounds play an increasing role in the treatment of skin disorders and wounds. Several new herbal drugs, medicinal products and... (Review)
Review
Herbal extracts and isolated plant compounds play an increasing role in the treatment of skin disorders and wounds. Several new herbal drugs, medicinal products and cosmetic products for the treatment of various skin conditions have been developed in recent years. In this nonsystematic review, we focus on herbal drugs that were tested in controlled clinical studies or in scientifically sound preclinical studies. The herbal biomedicines are intended to treat atopic dermatitis (St. John's wort, licorice, tormentil, bitter substances, evening primrose), psoriasis (araroba tree, lace flower, barberry bark, indigo, turmeric, olibanum, St. John's wort), actinic keratosis (birch bark, petty spurge), herpes simplex (lemon balm, sage and rhubarb), rosacea (green tea, licorice, tormentil) and acne vulgaris (tea tree oil, green tea, hop), or to improve photo protection (green tea, Dyer's weed, cocoa tree, carotinoids, licorice), aesthetic dermatology (licorice, pine bark, gotu kola) and wound healing (birch bark, onion).
PubMed: 32046246
DOI: 10.3390/biomedicines8020027 -
Biomedicines Oct 2022In 1903, Von Tappeiner and Jesionek [...].
In 1903, Von Tappeiner and Jesionek [...].
PubMed: 36359221
DOI: 10.3390/biomedicines10112701 -
Biomedicines Sep 2021This Special Issue of aims to outline nucleic-acid-based strategies that have emerged as tools to regulate specific gene expression and, more recently, as a new class...
This Special Issue of aims to outline nucleic-acid-based strategies that have emerged as tools to regulate specific gene expression and, more recently, as a new class of medicines [...].
PubMed: 34680472
DOI: 10.3390/biomedicines9101355 -
Biomedicines Aug 2022The celebration of one hundred years of insulin therapy in 2021 marked a milestone for the application of peptide-based therapeutics [...].
The celebration of one hundred years of insulin therapy in 2021 marked a milestone for the application of peptide-based therapeutics [...].
PubMed: 36009584
DOI: 10.3390/biomedicines10082037 -
Biomedicines Sep 2023The focus of this Special Issue on Biomedicines is on the value of "Biomarkers in Pain" from a broad perspective [...].
The focus of this Special Issue on Biomedicines is on the value of "Biomarkers in Pain" from a broad perspective [...].
PubMed: 37760995
DOI: 10.3390/biomedicines11092554 -
Biomedicines Nov 2023.
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PubMed: 38002069
DOI: 10.3390/biomedicines11113070 -
Biomedicines Oct 2023Many potential immune therapeutic targets are similarly affected in adult-onset neurodegenerative diseases, such as Alzheimer's (AD) disease, Parkinson's disease (PD),... (Review)
Review
Many potential immune therapeutic targets are similarly affected in adult-onset neurodegenerative diseases, such as Alzheimer's (AD) disease, Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS), and frontotemporal dementia (FTD), as well as in a seemingly distinct Niemann-Pick type C disease with primarily juvenile onset. This strongly argues for an overlap in pathogenic mechanisms. The commonly researched immune targets include various immune cell subsets, such as microglia, peripheral macrophages, and regulatory T cells (Tregs); the complement system; and other soluble factors. In this review, we compare these neurodegenerative diseases from a clinical point of view and highlight common pathways and mechanisms of protein aggregation, neurodegeneration, and/or neuroinflammation that could potentially lead to shared treatment strategies for overlapping immune dysfunctions in these diseases. These approaches include but are not limited to immunisation, complement cascade blockade, microbiome regulation, inhibition of signal transduction, Treg boosting, and stem cell transplantation.
PubMed: 37893165
DOI: 10.3390/biomedicines11102793 -
Biomedicines Dec 2022The Special Issue (BSI) of "Pathogenesis and Targeted Therapy of Epilepsy" seeks papers providing new insights into the roles of voltage-gated and ligand-gated ion...
The Special Issue (BSI) of "Pathogenesis and Targeted Therapy of Epilepsy" seeks papers providing new insights into the roles of voltage-gated and ligand-gated ion channels and their related signaling in the pathogenesis and pathophysiology of acquired epilepsy and inherited epilepsy [...].
PubMed: 36551890
DOI: 10.3390/biomedicines10123134 -
Biomedicines Aug 2022The history of medicine is also the history of our understanding of the role of neutrophils in protecting our bodies [...].
The history of medicine is also the history of our understanding of the role of neutrophils in protecting our bodies [...].
PubMed: 36009587
DOI: 10.3390/biomedicines10082040