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Biomedicines May 2023Over the past 70 years, significant progress has been made in understanding the molecular and cellular mechanisms of inflammation and tissue regeneration [...].
Over the past 70 years, significant progress has been made in understanding the molecular and cellular mechanisms of inflammation and tissue regeneration [...].
PubMed: 37239087
DOI: 10.3390/biomedicines11051416 -
Biomedicines Nov 2021In this Special Issue of on disease-focused research using stem cells, we cover the latest conceptual and practical advances in stem cell-based therapies and disease...
In this Special Issue of on disease-focused research using stem cells, we cover the latest conceptual and practical advances in stem cell-based therapies and disease modeling [...].
PubMed: 34829871
DOI: 10.3390/biomedicines9111643 -
Biomedicines May 2023Gastrointestinal diseases (GIDs) involve various benign and malignant pathologies of the digestive tract, as well as the liver, biliary tract, and pancreas [...].
Gastrointestinal diseases (GIDs) involve various benign and malignant pathologies of the digestive tract, as well as the liver, biliary tract, and pancreas [...].
PubMed: 37239091
DOI: 10.3390/biomedicines11051420 -
Biomedicines Sep 2023Bones and cartilage, the two most important parts of the musculoskeletal system, provide mobility and maintain the body's posture [...].
Bones and cartilage, the two most important parts of the musculoskeletal system, provide mobility and maintain the body's posture [...].
PubMed: 37760933
DOI: 10.3390/biomedicines11092492 -
Biomedicines Apr 2021In this Special Issue of Biomedicines, we have many insightful reviews and research papers on the subject "Macrophages in Health and Non-infectious Disease", but first;...
In this Special Issue of Biomedicines, we have many insightful reviews and research papers on the subject "Macrophages in Health and Non-infectious Disease", but first; we should discuss briefly the current situation in the field [...].
PubMed: 33922416
DOI: 10.3390/biomedicines9050460 -
Biomedicines Nov 2018Cancer is the second leading cause of death globally and remains a major economic and social burden. Although our understanding of cancer at the molecular level... (Review)
Review
Cancer is the second leading cause of death globally and remains a major economic and social burden. Although our understanding of cancer at the molecular level continues to improve, more effort is needed to develop new therapeutic tools and approaches exploiting these advances. Because of its high efficiency and accuracy, the CRISPR-Cas9 genome editing technique has recently emerged as a potentially powerful tool in the arsenal of cancer therapy. Among its many applications, CRISPR-Cas9 has shown an unprecedented clinical potential to discover novel targets for cancer therapy and to dissect chemical-genetic interactions, providing insight into how tumours respond to drug treatment. Moreover, CRISPR-Cas9 can be employed to rapidly engineer immune cells and oncolytic viruses for cancer immunotherapeutic applications. Perhaps more importantly, the ability of CRISPR-Cas9 to accurately edit genes, not only in cell culture models and model organisms but also in humans, allows its use in therapeutic explorations. In this review, we discuss important considerations for the use of CRISPR/Cas9 in therapeutic settings and major challenges that will need to be addressed prior to its clinical translation for a complex and polygenic disease such as cancer.
PubMed: 30424477
DOI: 10.3390/biomedicines6040105 -
Biomedicines Mar 2023Paraneoplastic conditions such as cancer cachexia are often exacerbated by chemotherapy, which affects the patient's quality of life as well as the response to therapy.... (Review)
Review
Paraneoplastic conditions such as cancer cachexia are often exacerbated by chemotherapy, which affects the patient's quality of life as well as the response to therapy. The aim of this narrative review was to overview the body-composition-related changes and molecular effects of different chemotherapy agents used in cancer treatment on skeletal-muscle remodeling. A literature search was performed using the Web of Science, Scopus, and Science Direct databases and a total of 77 papers was retrieved. In general, the literature survey showed that the molecular changes induced by chemotherapy in skeletal muscle have been studied mainly in animal models and mostly in non-tumor-bearing rodents, whereas clinical studies have essentially assessed changes in body composition by computerized tomography. Data from preclinical studies showed that chemotherapy modulates several molecular pathways in skeletal muscle, including the ubiquitin-proteasome pathway, autophagy, IGF-1/PI3K/Akt/mTOR, IL-6/JAK/STAT, and NF-κB pathway; however, the newest chemotherapy agents are underexplored. In conclusion, chemotherapy exacerbates skeletal-muscle wasting in cancer patients; however, the incomplete characterization of the chemotherapy-related molecular effects on skeletal muscle makes the development of new preventive anti-wasting strategies difficult. Therefore, further investigation on molecular mechanisms and clinical studies are necessary.
PubMed: 36979884
DOI: 10.3390/biomedicines11030905 -
Biomedicines May 2023Wound healing in general is a complex physiological process [...].
Wound healing in general is a complex physiological process [...].
PubMed: 37239051
DOI: 10.3390/biomedicines11051380 -
Biomedicines May 2023Polycystic ovary syndrome (PCOS) is an endocrine systemic disorder with a prevalence of between 5% and 20% that commonly affects childbearing-aged women [...].
Polycystic ovary syndrome (PCOS) is an endocrine systemic disorder with a prevalence of between 5% and 20% that commonly affects childbearing-aged women [...].
PubMed: 37239028
DOI: 10.3390/biomedicines11051358 -
International Journal of Nanomedicine 2014Fullerenes are among the strongest antioxidants and are characterized as "radical sponges." The research on biomedicinal applications of fullerenes has achieved... (Review)
Review
Fullerenes are among the strongest antioxidants and are characterized as "radical sponges." The research on biomedicinal applications of fullerenes has achieved significant progress since the landmark publication by Friedman et al in 1993. Fullerene-biomolecule conjugates have become an important area of research during the past 2 decades. By a thorough literature search, we attempt to update the information about the synthesis of different types of fullerene-biomolecule conjugates, including fullerene-containing amino acids and peptides, oligonucleotides, sugars, and esters. Moreover, we also discuss in this review recently reported data on the biological and pharmaceutical utilities of these compounds and some other fullerene derivatives of biomedical importance. While within the fullerene-biomolecule conjugates, in which fullerene may act as both an antioxidant and a carrier, specific targeting biomolecules conjugated to fullerene will undoubtedly strengthen the delivery of functional fullerenes to sites of clinical interest.
Topics: Antioxidants; Biopolymers; Drug Compounding; Fullerenes; Nanocapsules; Particle Size
PubMed: 24379667
DOI: 10.2147/IJN.S52829