Pharmacologic Substance
econazole
Brand Names:
Ecoza
Effect:
Decreased Cell Wall Integrity
May Treat:
Candidiasis, Cutaneous; Tinea Pedis; Tinea Versicolor
More Information:
ChemID; DrugBank; DailyMed; DrugInfo; PDR
Definitions related to econazole:
  • An imidazole derivative that is commonly used as a topical antifungal agent.
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2021
  • An imidazole with antifungal property. Econazole compromises the integrity of fungal cell wall through inhibiting 14-alpha demethylase, which catalyzes conversion of lanosterol to ergosterol, an essential component of the fungal cell wall. As a result, this agent increases cellular permeability thereby resulting in leakage of cellular contents. Furthermore, econazole has also been implicated to inhibit endogenous respiration, interact with membrane phospholipids, inhibit purine uptake, and impair triglyceride and/or phospholipid biosynthesis.
    NCI Thesaurus
    U.S. National Cancer Institute, 2021
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