Pharmacologic Substance
etomidate
Brand Names:
Amidate
Effect:
Decreased CNS Organized Electrical Activity; General Anesthesia
May Prevent:
Pain
May Treat:
Brain Ischemia; Head Injuries, Closed; Pain; Status Epilepticus
More Information:
ChemID; DrugBank; DailyMed; PDR
Definitions related to etomidate:
  • An imidazole derivative with short-acting sedative, hypnotic, and general anesthetic properties. Etomidate appears to have gamma-aminobutyric acid (GABA) like effects, mediated through GABA-A receptor. The action enhances the inhibitory effect of GABA on the central nervous system by causing chloride channel opening events which leads to membrane hyperpolarization.
    NCI
    U.S. National Cancer Institute, 2021
  • Imidazole derivative anesthetic and hypnotic with little effect on blood gases, ventilation, or the cardiovascular system. It has been proposed as an induction anesthetic.
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2025
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