Pharmacologic Substance
pimozide
Brand Names:
Orap
Effect:
Decreased Dopamine Activity; Increased Central Nervous System Dopamine Activity
May Treat:
Huntington Disease;
Psychotic Disorders;
Tourette Syndrome
More Information:
Definitions related to pimozide:
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A diphenylbutylpiperidine derivative and a dopamine antagonist with antipsychotic property. Pimozide selectively inhibits type 2 dopaminergic receptors in the central nervous system (CNS), thereby decreasing dopamine neurotransmission and reducing the occurrence of motor and vocal tics and delusions of parasitosis. In addition, this agent antagonizes alpha-adrenergic and 5-HT2 receptors.NCI ThesaurusU.S. National Cancer Institute, 2021
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A diphenylbutylpiperidine that is effective as an antipsychotic agent and as an alternative to HALOPERIDOL for the suppression of vocal and motor tics in patients with Tourette syndrome. Although the precise mechanism of action is unknown, blockade of postsynaptic dopamine receptors has been postulated. (From AMA Drug Evaluations Annual, 1994, p403)NLM Medical Subject HeadingsU.S. National Library of Medicine, 2021
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Diphenylbutylpiperidine that is used as an antipsychotic agent and as an alternative to haloperidol for the suppression of vocal and motor tics in patients with Tourette syndrome.CRISP ThesaurusNational Institutes of Health, 2006
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