Pharmacologic Substance
thiabendazole
thi·a·ben·da·zole
Brand Names:
Tresaderm
Effect:
Reproductive System Activity Alteration
May Treat:
Dracunculiasis;
Larva Migrans;
Strongyloidiasis;
Trichinellosis
More Information:
Definitions related to thiabendazole:
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2-Substituted benzimidazole first introduced in 1962. It is active against a variety of nematodes and is the drug of choice for STRONGYLOIDIASIS. It has CENTRAL NERVOUS SYSTEM side effects and hepatototoxic potential. (From Smith and Reynard, Textbook of Pharmacology, 1992, p919)NLM Medical Subject HeadingsU.S. National Library of Medicine, 2021
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A benzimidazole derivative with anthelminthic property. Although the mechanism of action has not been fully elucidated, thiabendazole inhibits the helminth-specific mitochondrial enzyme fumarate reductase, thereby inhibiting the citric acid cycle, mitochondrial respiration and subsequent production of ATP, ultimately leading to helminth's death. In addition, it has been suggested that thiabendazole may lead to inhibition of microtubule polymerization by binding to beta-tubulin and has an overt ovicidal effect with regard to some trichostrongylids.NCI ThesaurusU.S. National Cancer Institute, 2021
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