• (al amyloidosis) A plasma cell disorder characterized by the aggregation and deposition of insoluble amyloid fibrils derived from misfolding of monoclonal immunoglobulin light chains usually produced by a plasma cell tumor. It usually presents as primary systemic amyloidosis (PSA) with multiple organ involvement and less frequently as primary localized amyloidosis (PLA) restricted to a single organ.
  OrphaNet
  INSERM, 2021
• (al amyloidosis) The most common type of amyloidosis. It is characterized by the monoclonal deposition of immunoglobulin light chain fragments in organs and tissues. It is associated with plasma cell or B-cell lymphoproliferative disorders.
  NCI
  U.S. National Cancer Institute, 2021
• Amyloidosis caused by monoclonal deposition of immunoglobulin light chain and, rarely, heavy chain fragments in organs and tissues. It is associated with plasma cell or B-cell lymphoproliferative disorders.
  NCI
  U.S. National Cancer Institute, 2021
• (immunoglobulin light-chain amyloidosis) A nonproliferative disorder of PLASMA CELLS characterized by excessive production and misfolding of IMMUNOGLOBULIN LIGHT CHAINS that form insoluble amyloid fibrils (see AMYLOID DEPOSITS) in various tissues. Clinical features include LIVER FAILURE; MULTIPLE MYELOMA; NEPHROTIC SYNDROME; RESTRICTIVE CARDIOMYOPATHY, and neuropathies.
  NLM Medical Subject Headings
  U.S. National Library of Medicine, 2025
• AL amyloidosisis the most common form of amyloidosis, a group of disorders in which an abnormal protein called amyloid builds up in tissues and organs. The signs and symptoms of AL amyloidosis vary among patients because the build up may occur in the tongue, intestines, muscles, joints, nerves, skin, ligaments, heart, liver, spleen, or...
  NIH Genetic and Rare Diseases
  National Center for Advancing Translational Sciences