Pharmacologic Substance
sumatriptan Audio
su·ma·trip·tan
Brand Names:
Alsuma; Imitrex; Onzetra; Sumavel; Tosymra; Treximet; Zecuity; Zembrace
Effect:
Cerebral Arterial Vasoconstriction; Increased Central Nervous System Serotonin Activity
May Treat:
Cluster Headache; Migraine Disorders
More Information:
ChemID; DrugBank; DailyMed; PDR
Definitions related to sumatriptan:
  • A serotonin agonist that acts selectively at 5HT1 receptors. It is used in the treatment of MIGRAINE DISORDERS.
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2021
  • A sulfonamide triptan with vasoconstrictor activity. Sumatriptan selectively binds to and activates serotonin 5-HT1D receptors in the central nervous system (CNS), thereby constricting cerebral blood vessels. This may lead to a relief in pain from vascular headaches. Sumatriptan may also relieve vascular headaches by decreasing the release of vasoactive neuropeptides from perivascular trigeminal axons in the dura mater during a migraine, by reducing extravasation of plasma proteins, and by decreasing the release of other mediators of inflammation from the trigeminal nerve.
    NCI Thesaurus
    U.S. National Cancer Institute, 2021
  • Sulfonamide serotonin agonist and vasoconstrictor that acts selectively at 5HT1 receptors; frequently used in treating migraines.
    CRISP Thesaurus
    National Institutes of Health, 2006
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This content should not be used in place of medically-reviewed decision support reference material or professional medical advice. Some terms may have alternate or updated definitions not reflected in this set. The definitions on this page should not be considered complete or up to date.