Pharmacologic Substance
sumatriptan
su·ma·trip·tan
Brand Names:
Alsuma; Imitrex; Onzetra; Sumavel; Tosymra; Treximet; Zecuity; Zembrace
Effect:
Cerebral Arterial Vasoconstriction; Increased Central Nervous System Serotonin Activity
May Treat:
Cluster Headache;
Migraine Disorders
More Information:
Definitions related to sumatriptan:
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A serotonin agonist that acts selectively at 5HT1 receptors. It is used in the treatment of MIGRAINE DISORDERS.NLM Medical Subject HeadingsU.S. National Library of Medicine, 2021
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A sulfonamide triptan with vasoconstrictor activity. Sumatriptan selectively binds to and activates serotonin 5-HT1D receptors in the central nervous system (CNS), thereby constricting cerebral blood vessels. This may lead to a relief in pain from vascular headaches. Sumatriptan may also relieve vascular headaches by decreasing the release of vasoactive neuropeptides from perivascular trigeminal axons in the dura mater during a migraine, by reducing extravasation of plasma proteins, and by decreasing the release of other mediators of inflammation from the trigeminal nerve.NCI ThesaurusU.S. National Cancer Institute, 2021
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Sulfonamide serotonin agonist and vasoconstrictor that acts selectively at 5HT1 receptors; frequently used in treating migraines.CRISP ThesaurusNational Institutes of Health, 2006
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