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The Journal of Antibiotics Apr 1978
Topics: Amidohydrolases; Corynebacterium; Fatty Acids; Lipopeptides; Oligopeptides
PubMed: 659333
DOI: 10.7164/antibiotics.31.373 -
Journal of Clinical Microbiology Dec 2018spp. are rarely considered pathogens, but data on spp. as a cause of orthopedic infections are sparse. Therefore, we asked how often spp. caused an infection in a... (Comparative Study)
Comparative Study
spp. are rarely considered pathogens, but data on spp. as a cause of orthopedic infections are sparse. Therefore, we asked how often spp. caused an infection in a defined cohort of orthopedic patients with a positive culture. In addition, we aimed to determine the species variety and the susceptibility of isolated strains to define potential treatment strategies. We retrospectively assessed all bone and joint samples that were collected between 2006 and 2015 from an orthopedic ward and that were positive for spp. by culture. The isolates were considered relevant to an infection if the same sp. was present in at least two samples. We found 97 orthopedic cases with isolation of spp. (128 positive samples). These were mainly ( = 26), ( = 17), ( = 13), and ( = 11). Compared to the species found in a cohort of patients with positive blood cultures hospitalized in nonorthopedic wards, we found significantly more - and -positive cases but no -positive cases in our orthopedic cohort. Only 16 out of 66 cases (24.2%) with an available diagnostic set of at least two samples had an infection. Antibiotic susceptibility testing (AST) showed various susceptibility results for all antibiotics except vancomycin and linezolid, to which 100% of the isolates were susceptible. The rates of susceptibility of corynebacteria isolated from orthopedic samples and of isolates from blood cultures were comparable. In conclusion, our study results confirmed that a sp. is most often isolated as a contaminant in a cohort of orthopedic patients. AST is necessary to define the optimal treatment in orthopedic infections.
Topics: Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Arthritis, Infectious; Bacteremia; Bone Diseases, Infectious; Corynebacterium; Corynebacterium Infections; Female; Humans; Male; Microbial Sensitivity Tests; Middle Aged; Retrospective Studies
PubMed: 30305384
DOI: 10.1128/JCM.01200-18 -
Corynebacterium pseudodiphtheriticum: Putative probiotic, opportunistic infector, emerging pathogen.Virulence 2015
Topics: Animals; Corynebacterium; Corynebacterium Infections; Humans; Opportunistic Infections; Probiotics; Respiratory Tract Infections; Symbiosis
PubMed: 26252066
DOI: 10.1080/21505594.2015.1067747 -
Revista Chilena de Infectologia :... Dec 2009
Topics: Corynebacterium; Corynebacterium Infections; Humans
PubMed: 20098790
DOI: No ID Found -
Journal of Clinical Microbiology Oct 2012Catalase-positive Gram-positive bacilli, commonly called "diphtheroids" or "coryneform" bacteria were historically nearly always dismissed as contaminants when recovered... (Review)
Review
Catalase-positive Gram-positive bacilli, commonly called "diphtheroids" or "coryneform" bacteria were historically nearly always dismissed as contaminants when recovered from patients, but increasingly have been implicated as the cause of significant infections. These taxa have been underreported, and the taxa were taxonomically confusing. The mechanisms of pathogenesis, especially for newly described taxa, were rarely studied. Antibiotic susceptibility data were relatively scant. In this minireview, clinical relevance, phenotypic and genetic identification methods, matrix-assisted laser desorption ionization-time of flight (MALDI-TOF) evaluations, and antimicrobial susceptibility testing involving species in the genus Corynebacterium and other medically relevant Gram-positive rods, collectively called coryneforms, are described.
Topics: Anti-Bacterial Agents; Catalase; Corynebacterium; Corynebacterium Infections; Genotype; Humans; Microbial Sensitivity Tests; Molecular Diagnostic Techniques; Phenotype; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
PubMed: 22837327
DOI: 10.1128/JCM.00796-12 -
Molecular Microbiology Mar 2010Mycobacterium tuberculosis (M. tb) has a complex lifestyle in different environments and involving several developmental stages. The success of M. tb results from its... (Review)
Review
Mycobacterium tuberculosis (M. tb) has a complex lifestyle in different environments and involving several developmental stages. The success of M. tb results from its remarkable capacity to survive within the infected host, where it can persist in a non-replicating state for several decades. The survival strategies developed by M. tb are linked to the presence of an unusual cell envelope. However, little is known regarding its capacity to modulate and adapt production of cell wall components in response to environmental conditions or to changes in cell shape and cell division. Signal sensing leading to cellular responses must be tightly regulated to allow survival under variable conditions. Although prokaryotes generally control their signal transduction processes through two-component systems, signalling through Ser/Thr phosphorylation has recently emerged as a critical regulatory mechanism in bacteria. The genome of M. tb possesses a large family of eukaryotic-like Ser/Thr protein kinases (STPKs). The physiological roles of several mycobacterial STPK substrates are connected to cell shape/division and cell envelope biosynthesis. Although these regulatory mechanisms have mostly been studied in Mycobacterium, Ser/Thr phosphorylation appears also to regulate cell division and peptidoglycan synthesis in Corynebacterium and Streptomyces. This review focuses on the proteins which have been identified as STPK substrates and involved in the synthesis of major cell envelope components and cell shape/division in actinomycetes. It is also intended to describe how phosphorylation affects the activity of peptidoglycan biosynthetic enzymes or cell division proteins.
Topics: Adaptation, Physiological; Bacterial Proteins; Cell Division; Cell Wall; Corynebacterium; Gene Expression Regulation, Bacterial; Models, Biological; Mycobacterium tuberculosis; Peptidoglycan; Phosphorylation; Protein Serine-Threonine Kinases; Signal Transduction; Streptomyces
PubMed: 20487298
DOI: 10.1111/j.1365-2958.2009.07041.x -
Revista Espanola de Quimioterapia :... Jun 2021
Topics: Corynebacterium; Humans; Otitis
PubMed: 33715319
DOI: 10.37201/req/144.2020 -
Journal of Infection in Developing... Jan 2022Members of the Corynebacterium cystitidis species are usually isolated from kidney and urine of cow having pyelonephritis. Nevertheless, we have isolated Corynebacterium...
INTRODUCTION
Members of the Corynebacterium cystitidis species are usually isolated from kidney and urine of cow having pyelonephritis. Nevertheless, we have isolated Corynebacterium cystitidis for the first time from uterus of camels, extending the type of mammalian host for this species. Furthermore, it remains unknown whether there are significant genetic variations between strains isolated from different host species and anatomic sites. In this perspective, we investigated the genomic diversity of Corynebacterium cystitidis species, whose pan genome remain unexplored to date.
METHODOLOGY
Thus, we sequenced and compared the genomes of five Corynebacterium cystitidis of camel origin and a public genome of cow associated Corynebacterium cystitidis.
RESULTS
Results revealed open pan genome of 4,038 gene clusters and horizontal gene transfer played a role in the extensive genetic diversity. Further, we found an obvious distinction between cow and camel associated C. cystitidis via phylogenomic analysis and by average nucleotide identity value of 95% between the two distant lineages and > 99% within camel associated C. cystitidis strains. Moreover, our data supports the hypothesis that the gene repertoire of cow associated Corynebacterium cystitidis developed so as to become more adaptable to the urine milieu. These genetic potentials are specifically evident for genes required for benzoate breakdown, iron transport, citrate and alanine utilization.
CONCLUSIONS
Our findings confirm the differentiation of strains into camel lineage and cow lineage. These different niches, comprising the uterus of camel and urinary tract of cow probably played a role in shaping the gene repertoire of strains.
Topics: Animals; Camelus; Cattle; Corynebacterium; Female; Genomics; Phylogeny; Uterus
PubMed: 35192531
DOI: 10.3855/jidc.15023 -
Revista Chilena de Infectologia :... Dec 2005
Topics: Adolescent; Adult; Corynebacterium; Corynebacterium Infections; Humans; Terminology as Topic
PubMed: 16341357
DOI: 10.4067/s0716-10182005000600008 -
BMJ Case Reports Jul 2021A 10-year-old boy treated for alkali injury with multiple interventions presented with a perforated corneal ulcer with clinically suspected bacterial aetiology. Cornea...
A 10-year-old boy treated for alkali injury with multiple interventions presented with a perforated corneal ulcer with clinically suspected bacterial aetiology. Cornea scraping and tissue adhesive application were planned. During surgery, an eyelash was found embedded at the perforated site. Gram staining of corneal scraping revealed the presence of Gram-positive bacilli on the first day which later was identified as with culture followed by VITEK V.2.0 (Biomerieux) identification. The bacterium was found to be sensitive to amikacin, ciprofloxacin, cefazolin, gatifloxacin, moxifloxacin, ofloxacin and vancomycin antibiotics as per Clinical and Laboratory Standards Institute guidelines. Coryneform bacteria is a rare cause of keratitis, and this is the first reported case of microbial keratitis caused by one of the rare corynebacterium species to the best of our knowledge. Literature search does not reveal any specific ocular features typical to this organism. This case supports the growing evidence for pathogenicity of in ocular samples. This study demonstrates the utility of VITEK for the identification of rare pathogen and may facilitate the use of certain antibiotics in the treatment regimen of infections.
Topics: Anti-Bacterial Agents; Child; Corynebacterium; Eye Infections, Bacterial; Humans; Keratitis; Male; Microbial Sensitivity Tests; Ofloxacin
PubMed: 34210697
DOI: 10.1136/bcr-2020-241371