Pharmacologic Substance
dexmedetomidine
Brand Names:
Dexased; Dexdomitor; Dexmedesed; Precedex; Sedexodine; Sileo
Effect:
Decreased Organized Electrical Activity; Increased Norepinephrine Activity
May Treat:
Pain; Psychomotor Agitation
More Information:
ChemID; DrugBank; DailyMed; PDR
Definitions related to dexmedetomidine:
  • An imidazole derivative that is an agonist of ADRENERGIC ALPHA-2 RECEPTORS. It is closely related to MEDETOMIDINE, which is the racemic form of this compound.
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2025
  • An imidazole derivate and active d-isomer of medetomidine with analgesic, anxiolytic and sedative properties. Dexmedetomidine selectively binds to presynaptic alpha-2 adrenoceptors located in the brain, thereby inhibiting the release of norepinephrine from synaptic vesicles. This leads to an inhibition of postsynaptic activation of adrenoceptors, which inhibit sympathetic activity, thereby leading to sedation and anxiolysis. The analgesic effect of this agent is mediated by binding to alpha-2 adrenoceptors in the spinal cord.
    NCI
    U.S. National Cancer Institute, 2021
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