Pharmacologic Substance
phentolamine Audio
phen·tol·a·mine [ fen-tol-uh-meen, -min ]
Brand Names:
OraVerse
Effect:
Arterial Vasodilation; Decreased Blood Pressure; Positive Chronotropy; Positive Inotropy
May Treat:
Extravasation of Diagnostic and Therapeutic Materials; Hypertension, Malignant; Necrosis
More Information:
ChemID; DrugBank; DailyMed; PDR
Definitions related to phentolamine:
  • A nonselective alpha-adrenergic antagonist. It is used in the treatment of hypertension and hypertensive emergencies, pheochromocytoma, vasospasm of RAYNAUD DISEASE and frostbite, clonidine withdrawal syndrome, impotence, and peripheral vascular disease.
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2025
  • A synthetic imidazoline with alpha-adrenergic antagonist activity. As a competitive alpha-adrenergic antagonist, phentolamine binds to alpha-1 and alpha-2 receptors, resulting in a decrease in peripheral vascular resistance and vasodilatation. This agent also may block 5-hydroxytryptamine (5-HT) receptors and stimulate release of histamine from mast cells.
    NCI
    U.S. National Cancer Institute, 2021
  • Nonselective alpha-adrenergic antagonist.
    CRISP Thesaurus
    National Institutes of Health, 2006
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