-
British Medical Journal Feb 1977
Topics: Animals; Brucellosis; Brucellosis, Bovine; Cattle; Humans; United Kingdom
PubMed: 837164
DOI: No ID Found -
British Medical Journal Mar 1973
Topics: Acute Disease; Adolescent; Adult; Animals; Anti-Bacterial Agents; Antibodies, Bacterial; Biopsy; Brucella abortus; Brucellosis; Child; Chronic Disease; Female; Humans; Liver; Male; Middle Aged; Milk; Occupational Diseases; Pregnancy; Pregnancy Complications, Infectious; Serologic Tests
PubMed: 4632862
DOI: 10.1136/bmj.1.5856.791 -
The Journal of the Royal College of... Sep 1969
Topics: Animals; Brucellosis; Cattle; Humans; Scotland; Serologic Tests
PubMed: 5393849
DOI: No ID Found -
European Review For Medical and... Jul 2022Human brucellosis is a zoonosis with an extremely wide spectrum of clinical manifestations. Focal splenic involvement is very uncommon, particularly in the pediatric age... (Review)
Review
OBJECTIVE
Human brucellosis is a zoonosis with an extremely wide spectrum of clinical manifestations. Focal splenic involvement is very uncommon, particularly in the pediatric age group, during the illness' acute phase.
CASE REPORT
A 4-year-old boy, already receiving third-generation cephalosporin treatment, was transferred from a local hospital to the University Pediatric Department for fever, anemia, increased inflammation index, and multiple, hyper-echogenic splenic lesions on abdominal ultrasound. Initial diagnostic laboratory investigations for Brucella infection, including the Widal-Wright test, were found to be negative. However, further diagnostic laboratory analysis using the chemiluminescent immunoassay was positive for Brucella IgM antibodies. Treatment with rifampicin at a dose of 150 mg/Kg/twice daily and co-trimethoprim at a dose of 80 mg/Kg/twice daily was started and continued for 7 weeks. IgM antibodies were undetectable after 2 weeks of treatment, and after 6 weeks of treatment, abdominal ultrasound documented a reduction of the diameter of the major splenic infiltrate from 1 to 0.5 cm. At 3 and 5 months of follow-up, re-evaluation of the abdominal lesions displayed complete resolution of the splenic lesions and a complete clinical recovery.
CONCLUSIONS
The present case and a literature review are presented in this study since a standard diagnostic laboratory evaluation for brucellosis may miss the diagnosis, and in suspected cases, the laboratory analysis should be extended. Splenic abscesses are known to be rare in brucellosis, but the diagnosis should be considered in children with severe focal lesions, as specific antibiotic treatment may result in complete clinical recovery.
Topics: Abscess; Anti-Bacterial Agents; Brucellosis; Child; Child, Preschool; Humans; Immunoglobulin M; Male; Splenic Diseases
PubMed: 35856378
DOI: 10.26355/eurrev_202207_29211 -
The Journal of International Medical... Dec 2020Although rare, brucellosis is endemic in the Kingdom of Saudi Arabia (KSA). In the case presented here, a neonate was born at 29 weeks gestation with severe respiratory...
Although rare, brucellosis is endemic in the Kingdom of Saudi Arabia (KSA). In the case presented here, a neonate was born at 29 weeks gestation with severe respiratory depression, pyrexia; hypotension and an elevated white blood cell count. Her mother was a 19-year-old pregnant woman who developed premature rupture of the membranes and went into labour early. Sepsis was suspected and so the neonate received dobutamine and empiric ampicillin/gentamicin. The mother reported visiting a farm during her pregnancy and so congenital brucellosis was considered a possibility. Blood cultures were positive for Gram-negative coccobacilli and serology confirmed the presence of and Antibiotic treatment was changed to rifampin/gentamicin/ciprofloxacin but on day 17 the baby deteriorated and gentamicin was discontinued and meropenem was added. The neonate gradually improved; meropenem was discontinued on day 24 and the baby was discharged from hospital on day 38.
Topics: Anti-Bacterial Agents; Antibodies, Bacterial; Brucellosis; Child; Female; Humans; Infant, Newborn; Rifampin; Saudi Arabia
PubMed: 33290133
DOI: 10.1177/0300060520975576 -
International Journal of Infectious... Sep 2022We report the case of a 58-year-old immunocompetent man from Algeria, who presented to the hospital with fever and hepatic cytolysis. Abdominal computed tomography scan...
We report the case of a 58-year-old immunocompetent man from Algeria, who presented to the hospital with fever and hepatic cytolysis. Abdominal computed tomography scan showed a homogeneous splenomegaly and a hypodense 12-mm mass on the posterior wall of the esophagus. After ruling out tuberculosis, the patient was diagnosed with brucellosis. Patient was cured after receiving 6 weeks of oral doxycycline and intravenous gentamicin during the 7 first days of therapy. Such treatment was considered as an acceptable alternative of the recommended first-line therapy. This case illustrates the diagnostic issues in the context of an authentic brucellosis presenting as upper gastrointestinal symptoms, with impaired general condition.
Topics: Animals; Anti-Bacterial Agents; Brucella melitensis; Brucellosis; Esophagus; Goats; Humans
PubMed: 35640829
DOI: 10.1016/j.ijid.2022.05.054 -
Revue Scientifique Et Technique... Aug 2002Brucellae infections have been documented world-wide over the years in a great variety of terrestrial wildlife species. Recently, brucellae infections have also been... (Review)
Review
Brucellae infections have been documented world-wide over the years in a great variety of terrestrial wildlife species. Recently, brucellae infections have also been reported in a wide variety of marine mammals. A very important consideration with regard to terrestrial brucellosis in wildlife is to distinguish between a spillover of infection from domestic animals and a sustainable infection in wild species. The probability of brucellosis becoming established and being sustainable in a species depends on a combination of factors including host susceptibility, infectious dose, contact with infected animals, management and environmental factors. In this context, the development of the game farming industry appears to have contributed to the re-emergence of brucellosis. The gold standard in brucellosis diagnosis remains the isolation of brucellae. If brucellosis is suspected in an animal or a wildlife population following positive serological results, attempts to isolate the organism should always be performed. The release of anti-brucellae vaccine strain in wildlife is of concern because this could lead to environmental contamination and infection of other wild species. Therefore, the appropriate dosage of the vaccine in target species as well as the safety of the vaccine in non-target species must be addressed in technical terms in order to assist decision-making regarding the management of wildlife brucellosis.
Topics: Animals; Animals, Wild; Brucellosis; Humans; Zoonoses
PubMed: 11974615
DOI: 10.20506/rst.21.2.1333 -
Journal of Preventive Medicine and... Jun 2021Brucellosis, a major zoonotic disease, is highly present in Iran, especially in Lorestan province. The aim of this study was to understand the issues related to... (Review)
Review
BACKGROUND
Brucellosis, a major zoonotic disease, is highly present in Iran, especially in Lorestan province. The aim of this study was to understand the issues related to Brucellosis utilizing the multiple streams framework.
METHODS
A two-step method was adopted: 1) assessment of brucellosis-related documents and 2) interviews with stakeholders. As a first step, all documents related to Brucellosis were reviewed at provincial and national levels. Policy documentation on health issues included the consultation of guidelines, rules and regulations, websites, reports, books, guides, and conferences. These documents were collected by referring to specialized centers, institutions, and organizations. In the second step, semi-structured interviews were conducted to determine the burden of disease with actors and stakeholders involved with the brucellosis program in the Lorestan province. More in detail, physicians, healthcare workers, managers, policy- and decision-makers were selected for interviews.
RESULTS
The problem stream was characterized by: 1) high prevalence of the disease, 2) traditional livestock production, 3) unsafe animal slaughtering, 4) centers for the sale and distribution of non-authorized dairy products, 5) raw milk and 6) traditional unsafe dairy products consumption, 7) incomplete livestock vaccination, 8) lack of knowledge of Brucellosis, 9) neighboring countries with high prevalence of Brucellosis, 10) lack of livestock quarantine, and 10) nomadic immigration. The policy stream was characterized by 1) primary healthcare networks, 2) guidelines, 3) medicines, insurance, and 4) diagnostic services. Finally, the political stream was characterized by: 1) support of the University of Medical Sciences, 2) sponsorship by the Ministry of Health and Medical Education, 3) Health transformation plan, and 4) Working Group on Health and Food Security in Lorestan.
CONCLUSION
This study examined the brucellosis-related agenda setting: if different issues are taken into consideration, it can be perceived as a health priority.
Topics: Animals; Brucellosis; Health Policy; Humans; Iran; Policy Making; Zoonoses
PubMed: 34604598
DOI: 10.15167/2421-4248/jpmh2021.62.2.2041 -
PloS One 2020Brucellosis is a ubiquitous zoonotic disease globally. It is endemic among bovines, sheep, and goats in Albania. The national control and eradication programs for...
BACKGROUND
Brucellosis is a ubiquitous zoonotic disease globally. It is endemic among bovines, sheep, and goats in Albania. The national control and eradication programs for brucellosis has been applied on sheep and goat farms as well as large dairy cattle farms, i.e., those with more than ten milking cows. The current study aims at estimating the herd and average individual animal prevalence of brucellosis in the national beef cattle herds, the missing information that was essential to propose the most appropriate control measures for this sub-population. Rose Bengal Test (RBT), Fluorescence Polarization Assay (FPA), and Enzyme-Linked Immunosorbent Assay (ELISA) were used as serological tests and classical bacteriology for isolation. Results were also used to investigate the difference in sensitivity between the assays used.
METHODOLOGY
In total, 655 animals from 38 beef cattle herds from six southern districts of Albania were sampled. Sera were tested using RBT, FPA, and ELISA. Fifteen positive cows and a bull from eight high-prevalence positive herds were slaughtered, and particular tissue samples were collected for bacteriology.
RESULTS
The overall herd seroprevalence in the tested beef cattle population was 55%, while the overall average within-herd prevalence (including only positive herds) was 38.3%, 42.7%, and 45.6% determined by the RBT, ELISA, and FPA, respectively. FPA was used for the first time in the diagnosis of bovine brucellosis in Albania, and its sensitivity was higher than RBT and ELISA. Three B. abortus strains were identified, two from the supra-mammary lymph node of two cows and one from the epididymis of a seropositive bull.
CONCLUSION
Brucellosis was highly prevalent in beef cattle in the southern part of Albania, and B. abortus was isolated from this subpopulation. To the best of our knowledge, this is the first statistically based survey of bovine brucellosis in beef herds in Albania. Using the FPA in parallel with other serological tests improved overall diagnostic sensitivity. Test and slaughter policy is not a rational approach for the control of brucellosis in beef cattle in Albania, and vaccination is only applicable, including strict control of the movement of animals.
Topics: Albania; Animals; Brucella; Brucellosis; Cattle; Female; Male; Seroepidemiologic Studies; Zoonoses
PubMed: 32134953
DOI: 10.1371/journal.pone.0229741 -
Revista Chilena de Infectologia :... Dec 2016Brucellosis is one of the most frequent zoonosis in most parts of the world. This zoonosis remains a great problem to public health in developing countries, although... (Review)
Review
INTRODUCTION
Brucellosis is one of the most frequent zoonosis in most parts of the world. This zoonosis remains a great problem to public health in developing countries, although developed countries have successfully controlled it. Mexico still shows a high annual brucellosis incidence in humans; thus, the country is considered around the world as an endemic brucellosis country.
AIM
To describe the connection/association between this zoonosis and the current epidemiological situation in the Mexican population.
METHODS
Perusal of research reports, epidemiological studies and veterinarian reviews performed in Mexico, using data bases such as PubMed, Thompson Reuters, Mesh research.
CONCLUSION
The risk of infection by Brucella in Mexico is associated with the consumption of unpasteurized dairy products, mainly fresh cheeses.
Topics: Animals; Brucellosis; Goat Diseases; Goats; Humans; Incidence; Mexico; Zoonoses
PubMed: 28146190
DOI: 10.4067/S0716-10182016000600007